Gut Microbiota in Patients with Pulmonary Tuberculosis Depending on the Drug Resistance Type before Treatment
Journal Title: Актуальна інфектологія - Year 2015, Vol 4, Issue 9
Abstract
The aim was to investigate violations of microbiota of the large intestine in patients with pulmonary tuberculosis depending on the type of drug resistance before treatment. Subjects and methods. Clinical and bacteriological signs of intestinal dysbiosis were analyzed in 40 patients with newly diagnosed pulmonary tuberculosis with preserved sensitivity of Mycobacterium tuberculosis (group 1), 50 patients with multi-drug resistant tuberculosis (group 2) and 20 patients with extensively drug resistant pulmonary tuberculosis (group 3), 30 healthy individuals. Results. In group 1 manifestations of dysbiosis were observed in 77.5 % of cases, in group 2 and 3 — in 96 and 100 % of cases, respectively. Microbiological manifestations of dysbiosis were detected in 92.7 % of the patients in group 1 and in 100 % of the patients in groups 2 and 3. Dysbacteriosis of the I stage was diagnosed in 20 % of the patients of group 1, in 8 % in group 2 and in 5 % in group 3. Dysbiotic violation of the II stage prevailed in the group 1 — 42.5 % of cases and was observed in groups 2 and 3 in 26 and 30 % of cases, respectively. Dysbacteriosis of the III stage occ — in 66 and 65 % of patients vs. 30 %, respectively. Conclusion. The results indicate a high incidence of intestinal dysbiosis in patients with pulmonary tuberculosis before the initial phase of treatment.
Authors and Affiliations
L. D. Todoriko, O. V. Pidverbetska
Keywords
Related Articles
- EP ID EP213847
- DOI -
- Views 85
- Downloads 0
Increasing Efficacy of Treatment in Patients with Steatohepatitis
This paper presents the results of a study of patients with nonalcoholic steatohepatitis, alcoholic steatohepatitis, and drug-induced liver injury. In patients with liver injury, changes in intestinal microflora were mar...
Occult HBV infection
The review focuses on terminology, causes, epidemiology, clinical significance of occult hepatitis B virus (HBV) infection (OBI). Attention is paid to the differences in the definitions of OBI given by the European, Ame...
The Value of Case History for the Diagnosis of Childhoods Diseases
The article shows the urgency of collecting qualitative epidemiological history. The possible manifestation of worm infestations is described. Particular attention is paid to the question of the selection of toys for chi...
Prevalence of autoimmune thyroiditis among women with vitamin D deficiency
Background. Vitamin D and its metabolites play an important clinical role due to their interrelationship with calcium homeostasis and bone metabolism. Vitamin D has major effects on nearly all cells of the immune system....
Herbal enterosorbent effect in newly diagnosed destructive pulmonary tuberculosis management
Background. The search for pathogenetic therapeutic methods aimed at improving the immune status of a patient with tuberculosis without prescribing of specific immunomodulators is still relevant. This became the basis fo...