Gut Microbiota-Induced 5-HT Synthesis and Obesity
Journal Title: Journal of Endocrinology and Diabetes - Year 2015, Vol 2, Issue 5
Abstract
Although the role of gut microbiota in type 2 diabetes and the therapeutic effects of metformin have recently been reported [1- 3], the intestinal microbiota composition may be also influenced by obesity. Microbiota depletion by antibiotic treatment promotes browning of white adipose tissue and improves insulin sensitivity in obese animals such as ob/ob mice and diet-induced obesity [4]. Such metabolic improvements are mediated by eosinophil infiltration, enriched type 2 cytokine signaling and M2 macrophage polarization in the subcutaneous white fat depots [4]. Microbiota composition may therefore influence insulin sensitivity.
Authors and Affiliations
Katsunori Nonogaki
Keywords
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- EP ID EP333339
- DOI 10.15226/2374-6890/2/5/00136
- Views 99
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