Haematological Alterations in Initially Diagnosed and Relapse/Recurrent Cases of Malaria: A Comparative Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 9
Abstract
ABSTRACT Introduction: Malaria is endemic in India with an estimated 70-100 million cases each year. An alteration of haematological profile is one of the hallmarks in patients with malaria. A variety of haematological alterations like progressively increasing anaemia, leucocytosis or leucopenia, thrombocytopenia have been reported. Aim: To evaluate and compare the effect of initially diagnosed cases and cases of relapse/ recurrence of malaria on haematological parameters and their correlation with Parasitic Index (PI). Materials and Methods: This prospective study included 183 patients of initially diagnosed malaria cases and 64 follow-up cases of malaria. The diagnosis of malaria was confirmed on peripheral blood film and/or malaria antigen test. Complete blood counts were performed using automated Sysmex XN-1000. MP antigen test was done by Alere bioline SD malaria antigen kit. The Pearson’s Chi-square test was used for comparison of the patient’s data for association between distribution of severe anaemia in initially diagnosed cases of malaria and in cases with relapse/recurrence in relation to PI. The association of Grade III & IV thrombocytopenia in initially diagnosed cases of malaria and in cases with relapse/recurrence in relation to PI was evaluated using the paired Student’s t-test. Results: Out of 183 initially diagnosed malaria cases, 163 cases had P. vivax and 20 cases had P. falciparum. All the cases of P. vivax and 75% of cases of P. falciparum had anaemia. All the cases had thrombocytopenia. Among 64 follow-up cases, 57 had P. vivax and 7 cases had P. falciparum infection. Approximately 50% cases of P. vivax and 40% cases of P. falciparum had normal Hb levels. Normal platelet counts were observed in 14% of P. vivax and 28.5% of P. falciparum cases. Majority of the cases (≅ 85%) of both the groups had PI ≤10. Conclusion: Anaemia and thrombocytopenia are frequent findings in malaria with severity of thrombocytopenia related to PI. Thrombocytopenia is a constant finding in initially diagnosed cases of malaria but in cases of relapse/recurrence platelet counts may be normal.
Authors and Affiliations
Deepti Arora
Cervical Vagal Schwannoma: Peculiarity in Diagnosis and Treatment
ABSTRACT Vagal Nerve Schwannoma (VS) is a rare tumour, usually seen in patients of 30-50 years of age, affecting both sexes equally. Clinically, VS presents as a slow growing, asymptomatic tumour, often with minimal symp...
Body Weight and Its Relationship with Muscle Strength among Adolescents in Malaysia
ABSTRACT Introduction: Few studies have investigated the relationship of handgrip strength as an index of nutritional status to morbidity and mortality in adults and elderly. However, it is not clear if differences exist...
Pathological and Biochemical Evaluation of Toxic Effects of Repeated Administration of Jasada Bhasma (Zinc Ash Formulation) in Wistar Albino Rats
Introduction: Jasada Bhasma is the well known potent zinc formulation commonly used in ‘Ayurveda’ medicine system. Its extensive usage in the health care sector is proved to be successful in the treatment of certain illn...
Emphysematous Pyelonephritis with Human Immunodeficiency Virus Infection
Letter to Editor
A Study on Expression of Vascular Endothelial Growth Factor in Colorectal Malignancies and its Correlation withVarious Clinicopathological Parameters
ABSTRACT Introduction: Tumours require neovascularisation for growth and metastasis. Vascular Endothelial Growth Factor (VEGF) is an important regulator of tumour angiogenesis and is associated with metastasis and poor...