HAEMATOLOGICAL CHANGES AND THEIR CORRELATION WITH THE DEGREE OF RENAL INSUFFICIENCY IN NEWLY DETECTED TYPE 2 DIABETES PATIENTS ATTENDING JNIMS OPD
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 31
Abstract
BACKGROUND There is an increasing number of patients with diabetes over the past decades, leading to higher incidence of chronic kidney disease in the affected group of patients. Haematological changes are well known clinical abnormality in patients with deteriorated renal function, which is emerging as a major health issue. In this study, we analysed the correlation of haematological changes with the degree of renal insufficiency in type II diabetes patients. MATERIALS AND METHODS This descriptive study was carried out from September 2015 to September 2017 for a period of 25 months in the Department of Pathology, and Diabetes OPD, Jawaharlal Nehru Institute of Medical Sciences, Porompat, Imphal. A total of 250 (two hundred and fifty) newly diagnosed diabetes cases from both the sexes were included in the study, as per inclusion and exclusion criteria. Diagnosis of the Diabetes was considered by following the criteria laid down by the American Diabetes Association, the European Association for the Study of Diabetes, and the International Diabetes Federation. All tests were carried out under standard procedure. RESULTS A total of 250 patients were taken for study. Maximum number of patients (65.2%) were found to be in the age group of 35-55 years. Majority of the patients (n=161) in the study were in stage 1 CKD followed by stage 2 (n=75) and stage 3a (n=12) and one patient in each of stage 3b and stage 4 CKD. Haemoglobin ranged from 6.9 gm% to 17.9 gm% with a mean haemoglobin of 13.28 gm%. Anaemia was prevalent in 20% of the cases. Mean Haematocrit or Packed Cell Volume was found to be 40.92±6.168% and was statistically significant (p value 0.027˂0.05). Mean ESR was found to be 25.64±19.089 mm/1st hour and p-value was statistically significant (p value=0.011˂0.05). Mean Absolute Eosinophil Count was found to be statistically significant (p value=0.035). Mean TLC, RDW, MCH, MCV, MCHC, Absolute Counts of Neutrophil, Lymphocyte and Monocyte were found to be not significant statistically. CONCLUSION Haematologic abnormalities are common in Diabetes, especially when associated with renal dysfunction. Anaemia is the most common haematologic abnormality observed. Normocytic normochromic anaemia and Microcytic hypochromic anaemia are the two types of anaemia observed. Maximum number of cases were in stage 1 of CKD with eGFR˃90 mL/min/1.73 m2. This may be because, in this study there were only newly diagnosed type 2 diabetes mellitus cases. ESR was higher with a mean value of 25.64±19.089 mm/1st hour and shows positive correlation with stages of CKD. The haematocrit was found to be statistically significant upon correlation with stages of CKD.
Authors and Affiliations
Kh. Rochitra Devi, Ksh. Achouba Singh, Mohan Singh Y.
Keywords
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- EP ID EP541023
- DOI 10.14260/jemds/2018/788
- Views 73
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