Haematological Disturbances in Dengue Haemorrhagic Fever - its Pathogenesis and Management Perspectives
Journal Title: Journal of Hematology and Oncology Research - Year 2015, Vol 1, Issue 3
Abstract
Haemorrhage is common to both dengue fever (DF) and dengue haemorrhagic fever (DHF). Thrombocytopaenia is exceedingly common, while prolonged partial thromboplastin time and reduced fibrinogen concentration are the other abnormal haemostatic indices evident from early in the disease course. These haematological abnormalities correlate better with the timing and severity of plasma leakage rather than the clinical haemorrhagic manifestations. Blood products including prophylactic platelet transfusions are hardly required in the management of DHF. Judicious fluid therapy is the most effective intervention to prevent complications and bleeding in DHF. Concealed haemorrhage is an important complication requiring early recognition and blood transfusions to improve outcomes. Understanding the pathogenesis of coagulopathy and the significance of altered haemostatic indices, and its co-relation to disease severity and phase of DHF, is essential for appropriate interventions particularly when DHF co-exists in patients on mandatory anticoagulation for prosthetic heart valves and atrial fibrillation.
Authors and Affiliations
Kolitha H Sellahewa
Keywords
Related Articles
- EP ID EP249477
- DOI 10.14302/issn.2372-6601.jhor-14-381
- Views 215
- Downloads 0
Factors that Influence Fenofibrate Effects on Cancer Cells
No Abstract
Haematological Disturbances in Dengue Haemorrhagic Fever - its Pathogenesis and Management Perspectives
Haemorrhage is common to both dengue fever (DF) and dengue haemorrhagic fever (DHF). Thrombocytopaenia is exceedingly common, while prolonged partial thromboplastin time and reduced fibrinogen concentration are the other...
Reduced Physical Activity Patterns in Patients with Thalassemia Compared to Healthy Controls
Background: Patients with Thal (Thalassemia) are presumed to be inactive for many of the same reasons as healthy adults, though there are limited published data to support this claim. The primary aim of this study was t...
Early Detection of Post-transplant Lymphoproliferative Disorder by Head and Neck Manifestations
Introduction: Post-transplant lymphoproliferative disease (PTLD) is a collection of conditions associated with abnormal proliferation of lymphoid tissues in patients after solid organ transplants (SOT). Its clinical pre...
Acute Onset Symptomatic Polycythaemia Vera
No Abstract