HAEMATOLOGICAL PARAMETERS AND VITAMIN B12 LEVELS IN TYPE II DIABETIC PATIENTS ON METFORMIN- A PROSPECTIVE CASE CONTROL STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 31
Abstract
BACKGROUND Metformin is the cornerstone medication in the management of type 2 diabetes mellitus (T2DM) with estimates that it is routinely prescribed to 120 million type 2 diabetes patients around the world. Preceding studies say long term use of metformin in T2DM lowers vitamin-B12 levels and its clinical manifestations can be misdiagnosed as diabetic peripheral neuropathy. The aim of this study is to correlate haematological parameters with estimated serum Vit. B12 levels in T2DM patients on long term metformin in patient subjects and healthy volunteers. MATERIALS AND METHODS A total of 34 T2DM patients (cases) and 34 healthy volunteers (controls) were enrolled in the study from the out-patient department and in-patient wards of RVM Hospital, for over a period of 6 months. Serum vitamin-B12, HbA1c and haematological parameters were measured. RESULTS The clinical characteristics and serum vitamin-B12 levels of the study population were compared using chi-square cross tabulation. Vitamin-B12 deficiency was higher in T2DM patients taking daily dose of metformin >1000 mg/day. Hematological parameters estimation and peripheral smear study was done in all cases to identify macrocytic anaemia and hyper segmented polymorphs. CONCLUSION The prevalence of vitamin-B12 deficiency in T2DM patients was found to be high in our study population when compared to control subjects. Peripheral smear study revealed macrocytic anaemia in 22.7% and hyper-segmented polymorphs in 50% of cases with B12 deficiency. Considering the regular screening of vitamin-B12 as cost factor, the peripheral smear can be done frequently in T2DM patients on long term metformin to detect macrocytic anaemia followed by biochemical analysis periodically in a rural areas.
Authors and Affiliations
Vijaya Lakshmi Koduri, Srinivas N. S Nori, Aditya Sai Rama Krishna K, Suhas Madaboina, Sindhuja A. B. K, Swati Sappa
Keywords
Related Articles
- EP ID EP570160
- DOI 10.18410/jebmh/2018/478
- Views 92
- Downloads 0
CLINICAL PROFILE OF PRIMARY LUNG CANCER AND ROLE OF BRONCHOSCOPY
Cancer is a Latin word meaning "A CRAB". The Greek word for a crab is "KARKINES" and Sanskrit word is "KARKARA” (1) Lung cancer is one of the commonest fatal neoplastic diseases in the world. It is at the first place at...
CORRELATION OF THYROID DYSFUNCTION WITH INSULIN RESISTANCE IN OBESE WOMEN
Thyroid dysfunction will be associated with insulin resistance in obese women were common. METHODS: In this cross-sectional study, a total of fifty female subjects with age group of 30-60 years, a whose body mass index w...
MYELOPATHY OR ATYPICAL PRESENTATION OF GBS
PRESENTATION OF CASE A 53-year-old male presented to the Emergency Department of ESI Hospital complaining of recent onset tingling and numbness in both of his legs about, which he described as feeling sleepy. The symptom...
STUDY OF MATERNAL AND PERINATAL OUTCOME IN MULTIFOETAL PREGNANCY
BACKGROUND Multifetal gestation is responsible for a disproportionate amount of overall perinatal mortality and morbidity. Multifetal pregnancies have increased due to fertility treatment for assisted reproductive techni...
A CLINICAL STUDY TO ANALYSE THE SPECTRUM OF PERITONITIS DUE TO HOLLOW VISCUS PERFORATION
Perforation peritonitis is the one of the common abdominal surgical emergency. The spectrum of etiology of perforation in Tropical countries continues to be different from its Western counterpart. The objective of the st...