Haematological Parameters in Children with Serum Folate Deficiency
Journal Title: Meandros Medical and Dental Journal - Year 2021, Vol 22, Issue 1
Abstract
Objective: Folate deficiency is common globally, especially in low- and middleincome countries. The best-known morbid effects of folate deficiency are haematological in nature. This study aimed to identify the haematological parameters status of folate deficiency in children. Materials and Methods: Data were gathered from the outpatient clinics electronic database of Gaziantep University Hospital. A total of 200 children were evaluated. The inclusion criteria were paediatric patients with folate deficiency (<4 ng/mL). Results: Of the 200 children with folate deficiency, 46.5% showed low haemoglobin level (<11 g/dL), reflecting anaemia status. Macrocytic anaemia was detected in 13.5% of the patients. Thrombocytopaenia was detected in 20%, leukopenia in 17%, lymphopaenia in 6%, neutropenia in 5% and pancytopenia in 12% of the patients. Positive correlations were found between folate levels and haemoglobin (r=0.18; p<0.01), haematocrit (r=0.17; p<0.05), red blood cell (r=0.19; p<0.01), lymphocyte count (r=0.20; p<0.01) and platelet count (r=0.15; p<0.05). However, inverse correlations were found between folate level and red cell distribution width (r=-0.18; p<0.01), and no correlations were noted between folate level and mean corpuscular volume (r=-0.72; p>0.05). Conclusion: Our data showed that these children not only develop anaemia but also leucopenia, thrombocytopenia and pancytopenia. Monitoring haematological parameters could be useful in children with folate deficiency.
Authors and Affiliations
Hatice Tuba Akbayram, Mustafa Örkmez
Keywords
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- EP ID EP693428
- DOI 10.4274/meandros.galenos.2021.92259
- Views 77
- Downloads 0
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