Haematological Profile of Rat Offspring Exposed To Beta Cypermethrin during the Perinatal Period
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 1
Abstract
Abstract:Cypermethrin, a broad spectrum insecticide, has been extensively used for pest management and animal husbandry practices. Previous studies have shown that cypermethrin has teratogenic effect on rat foeti born to exposed dam or buck with no information on its effect on their haematological profile. The present study was aimed to assess the haematological profile of rat offspring exposed to beta cypermethrin during the perinatal period. Fifteen pregnant animals (Day 0 = day of mating, average body-weight = 190g) were randomly divided into 3 groups. Group A (Control) received 0.5ml olive oil, Group B (15 mg/kg β-cyp) and Group C (30 mg/kg β-cyp,) by oral gavage from gestational day (GD) 1 – post natal day (PND) 20. The litter size and foeti weights were taken on PND 0, 7, 14 and 21. On GD 21, blood samples were collected from 5 pups from each group for haematology. β-cyp caused a significant (p< 0.05) decrease in the packed cell volume, haemoglobin concentration, platelets and red blood cell count. Significant (p< 0.05) decrease in foeti weights were observed on PND 14 and 21. It is concluded that β-cyp has a dose-dependent toxic effects on the haematology of albino rat offspring exposed during the perinatal period. Keywords:Beta-cypermethrin, Haematology, rat offspring, perinatal, litter size, foeti weights.
Authors and Affiliations
Victoria Chinenye Obinna, Hope Delesi Kagbo
Keywords
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