Haemostatic Profile of Patients with Chronic Liver Disease- its Correlation with Severity and Outcome
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 8
Abstract
Introduction: The liver plays an important role in the haemostatic system as it synthesizes the majority of coagulation factors and fibrinolytic proteins. Aim: The present study was planned to determine the range of haemostatic defects in patients of chronic liver diseases. Materials and Methods: Test performed included Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT), Thrombin Time (TT), Fibrinogen, Protein C, D Dimer and platelet count. Comparisons between groups frequencies and groups means were made using Chi-square test and Student’s t-test, respectively. Results: In cirrhosis group PT, aPTT, TT and D Dimer level were significantly increased compared to Chronic Hepatitis (CH) and control group (p<0.001 for all comparisons). Serum fibrinogen, Protein C and platelet count were significantly reduced in cirrhosis patients compared to CH and control group. (p<0.001 for all comparisons). All studied coagulation parameters were within normal limit in CH group. However, statistically significant difference was found in protein C and mean platelet count in CH group compared to control (p=0.03 and p<0.001 respectively). No evidence of bleeding or thrombosis was present in study group. Conclusion: In cirrhosis patients severe derangement in both anti and procoagulant factors occurs. Haemostatic profile in chronic hepatitis patient remains within normal limits.
Authors and Affiliations
Varnika Rai, Neeraj Dhameja, Sandip Kumar, Jyoti Shukla, Rajeev Singh, Vinod Kumar Dixit
Keywords
Related Articles
- EP ID EP358224
- DOI 10.7860/JCDR/2017/24975.10451
- Views 55
- Downloads 0
Crossed Fused Renal Ectopia showing Pelviureteric Junction Obstruction with Single Ureter and Single Renal Artery
ABSTRACT Crossed fused renal ectopia is a rare anomaly remaining asymptomatic by far and detected invariably as either incidental finding or in view of pre-existing kidney disease. We report a case of crossed fused renal...
Efficacy of Green Tea Extract for Treatment of Dry Eye and Meibomian Gland Dysfunction; A Double-blind Randomized Controlled Clinical Trial Study
Introduction: With an incidence rate of 9%, dry eye is a common problem of the ocular surface, especially in patients more than 40-year-old. Green tea extract has anti-oxidative, anti-bacterial, anti-androgen, and immuno...
Sibling Screening of a Case of Pyroglutamic Aciduria Resulting in Normal Development- A Case Report
ABSTRACT Pyroglutamic aciduria is a condition usually associated with metabolic acidosis and increased excretion of pyroglutamic acid in urine. It occurs due to metabolic defect in γ-glutamyl cycle. Here we report a case...
Supraclavicular Brachial Plexus Block: Comparision of Two Different Doses of Dexmedetomidine as an Adjunct to Bupivacaine: A Study
ABSTRACT Introduction: Supraclavicular brachial plexus block is commonly performed for upper limb surgeries. A variety of adjuvants are added to the local anaesthetic to fasten the onset and prolong the duration of sens...
Dental Avengers: Taking Retainer Stability and Aesthetics into Next Era
Adult patients are realizing that practical, realistic options now exist to “straighten” their teeth because the cosmetic dentistry revolution has begun to include even “adult short-term cosmetic orthodontics” as an inte...