HAIR GROWTH POTENTIAL OF EVOLVULUS ALSINOIDES LINN. PLANT EXTRACT IN ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Evolvulus alsinoides Linn. (Convolvulaceae) is traditionally used for its hair growth promoting activity in rural community of Indian sub-continent. Studies were therefore carried out to evaluate petroleum ether and methanolic extracts of Evolvulus alsinoides for their effect on hair growth in albino rats. The extracts were incorporated into oleaginous base and applied topically on shaved denuded skin of albino rats for thirty days. The time required for hair growth initiation and completion was significantly (P < 0.01) reduced. Minoxidil 2% solution applied topically served as positive control. The treatment was successful in bringing 73% of hair follicles in anagenic phase by application of 5% methanolic extract as comparable to standard. Bioactivity guided fractionation was carried out of methanolic extract and was fractionated as aqueous and non-aqueous extract and screened pharmacologically. Water insoluble methanolic extract was found to be more potent and reduced the hair growth initiation and completion time significantly (P < 0.01) as comparable to standard. It holds the promise of potent alternative for minoxidil.
Authors and Affiliations
Amrita Bhaiji , Umesh Patil , Suchi Dave , Arvind Jain , Himanshu Sahoo
Keywords
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