Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation

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Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation

Journal Title: EMBO Reports - Year 2008, Vol 9, Issue 6

Abstract

During the past decade, the lipid-raft hypothesis has focused attention on the role of membrane domains in controlling cellular functions. Among the best-studied roles of lipid rafts is the regulation of T-cell signalling. In particular, a model has emerged in which lipid rafts regulate protein–protein interactions during signalling in a cholesterol-dependent manner. Does this model provide the best description of what is happening in living cell membranes? Alternatively, has our ability to evaluate this question critically become compromised by the influential nature of the lipid-raft model itself? Here, this issue is explored in the context of two of the major tenets of the lipid-raft model.

Authors and Affiliations

Anne K Kenworthy

Keywords

The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes

The positive transcription elongation factor b (P-TEFb) is a heterodimeric complex composed of cyclin-dependent kinase 9 and its regulator cyclin T1/2. It stimulates transcription elongation by phosphorylation of serine...

EP ID EP679943
DOI 10.1038/embor.2008.92
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