HAZARDS TO HEARING FROM COMBINED EXPOSURE TO TOLUENE AND NOISE IN RATS

Abstract

[b]Introduction: [/b]The main risk of hearing impairment from workplace exposure to organic solvents may stem from the potentiation of effects caused by concomitant noise exposure. The aim of the present study was to identify the main hazards from combined long-term, low-level exposure to noise and aromatic organic solvents, like toluene, in rats. [b]Material and Methods:[/b] The rats were exposed to steady-state, wide-band noise (WBN) and 0 ppm, 100 ppm, 200 ppm and 500 ppm toluene for 90 days. Hearing was assessed using Auditory Brain Stem Responses (ABR) and Distortion Product Oto-Acoustic Emissions (DPOAE) eight weeks after exposure. The impact of noise composition on the interaction between solvent and noise exposure was investigated in rats exposed for 10 days either to 0 ppm, 500 ppm, 1000 ppm or 1500 ppm toluene and either WBN or impulse noise. ABR and DPOAE tests were performed before and two weeks after exposure. [b]Results:[/b] Long-term exposure of rats to WBN and toluene at 500 ppm or less did not show any increase in hearing impairment, compared to the rats exposed to noise only. Synergistic interaction was demonstrated in short-term exposure to 1500 ppm toluene and both to WBN and impulse noise, but hearing impairment was much larger when following exposure to impulse noise.[b] Conclusion:[/b] In combined exposure to low-levels of noise and toluene, even a long-term exposure did not reveal a potential hazard of hearing impairment. Synergistic interaction in combined short-term exposure to toluene and noise was noted both with respect to WBN and impulse noise, but the impulse noise was much more disruptive than WBN at the same level of noise exposure. The ototoxicity of organic solvents may primarily be a hazard also to human hearing due to the exacerbation of hearing loss by a possible co-exposure to especially harmful noise, such as impulse noise.

Authors and Affiliations

SØREN LUND, GITTE KRISTIANSEN

Keywords

Related Articles

DESCRIPTION OF A LARGE-SCALE STUDY DESIGN TO ASSESS WORK-STRESS-DISEASE ASSOCIATIONS FOR CARDIOVASULAR DISEASES

We claim that a new level of studies is needed to answer a series of important questions about the expanding global chronic disease burden for cardiovascular disease (CVD) and for related conditions such as diabetes, met...

Shift schedule, work–family relationships, marital communication, job satisfaction and health among transport service shift workers

Objectives: Existing research has documented that shiftwork consequences may depend on the shift system parameters. Fast rotating systems (1–3 shifts of the same kind in a row) and day work have been found to be less dis...

IL-18 LEVELS IN NASAL LAVAGE AFTER INHALATORY CHALLENGE TEST WITH FLOUR IN BAKERS DIAGNOSED WITH OCCUPATIONAL ASTHMA

[b]Objectives: [/b]The authors discuss the outcomes of a study on IL-18 concentration in nasal washings after the inhalatory challenge test with fl our allergens (ICHT-F) in bakers with fl our-induced occupational airway...

Solving the problem of smoking in the Polish enterprises during 2003–2015

Objectives: Tobacco smoking is a major organizational, economical, and public relations-related (PR-related) problem for the company. Moreover, it is an important health determinant of the working population. The paper r...

Spirometric and hygienic criteria in recognition of occupational COPD in Poland – A retrospective analysis of medical records

Objectives: Chronic obstructive pulmonary disease (COPD) may be work-related. It has been estimated that 15% of the population burden of COPD is attributable to occupational exposure. However, in Poland COPD is rarely re...

Download PDF file
  • EP ID EP102283
  • DOI 10.2478/v10001-008-0008-x
  • Views 99
  • Downloads 0

How To Cite

SØREN LUND, GITTE KRISTIANSEN (2008). HAZARDS TO HEARING FROM COMBINED EXPOSURE TO TOLUENE AND NOISE IN RATS. International Journal of Occupational Medicine and Environmental Health, 21(1), 47-57. https://europub.co.uk/articles/-A-102283