HBeAg Negativity is Associated with a Higher Risk of Liver-Related Death in Patients with Chronic Hepatitis B Related Liver Cirrhosis
Journal Title: Diseases & Research - Year 2022, Vol 2, Issue 1
Abstract
Background and aims Few studies reported the association between the survival of patients with chronic hepatitis B (CHB)-related liver cirrhosis (LC) and hepatitis B e antigen (HBeAg) state. Methods Three hundred and ninety-eight CHB-LC patients from two institutions were included. To adjust for selection bias, propensity score matching (PSM) with 1:1 ratio was used to balance clinical features between HBeAg-positive and HBeAg-negative CHB-LC patients. The related factors of liver-related death were identified by cox regression analysis, while the difference of survival was analyzed using Kaplan–Meier curves. Results Two hundred and eighty-eight (72.4%) CHB-LC patients were HBeAg negative, and the median follow-up time was 33.9 months. Fifty-two liver-related deaths occurred during the follow-up period. The liver-related mortality in HBeAg-negative CHB-LC patients was comparable with HBeAg-positive patients before PSM (14.2% vs. 22.3%, P = 0.094). After PSM for age, sex, platelet count, ALT level, and HBV DNA, 77 patients were matched in each group. Higher liver-related mortality was observed in patients with HBeAg-negative CHB-LC than those of HBeAg-positive CHB-LC patients (39.6% vs. 18.7%, P = 0.019). Patients with decompensated LC had similar results. Furthermore, HBeAg-negative state was identified as a significantly risk factor of liver-related mortality (HR, 3.032; 95% CI, 1.232–7.460; P = 0.016). Conclusions HBeAg-negative state may be an independent risk factor of liver-related mortality in patients with CHB-LC.
Authors and Affiliations
Jian Wang, Shengxia Yin, Li Zhu, Jiacheng Liu, Ruifei Xue, Yu Geng, Juan Xia, Yali Xiong, Weihua Wu, Xin Tong, Xiaomin Yan, Yuxin Chen, Chuanwu Zhu, Rui Huang, Chao Wu
Keywords
Related Articles
- EP ID EP740155
- DOI 10.54457/DR.202201004
- Views 24
- Downloads 1
Determination of mRNA Targets of miR-376c within the RNA-Induced Silencing Complex
Background The focus of the present study was to establish an easy combined method based on the MirTrap system together with a mRNA array to efficiently define target mRNAs which can be bound by miR-376 within the RNA-in...
Liquid Biopsies: As an Emerging Tool in Cancer Diagnosis and Monitoring Therapies in Metastasis
Despite the availability of advanced diagnosis and treatment methods, cancer is still a leading cause of morbidity. The most readily and routinely available method for cancer diagnosis is tissue biopsy. Tissue biopsies a...
Successful Treatment with CAR- T Cells in a Patient with Immune Thrombocytopenia Associated with Castleman Disease
Multicentric Castleman disease (MCD), a rare lymphoproliferative disorder of incompletely understood etiology, is manifested as enlarged multiple lymph node and multiple organs involvement. The best therapeutic option fo...
Anti-Cancer Agents Work in Antagonism with Inhibitors of HSP 72
Purpose The heat shock genes are evidenced to be active in the migration and are major promoters of several human malignancies. The inclined expression of HSP 72 proteins play an inevitable role in protecting cancer cell...
Effect of Comparison between Qingchangligan Granules and Qingchangligan Decoction on D-GalN/LPS-Induced Liver Injury in Mice
Ethnopharmacological relevance The Qingchangligan formula has two dosage forms, granules and decoction. Both of them have the same prescription; however, whether their protective effects are different remain elusive. Ai...