HBeAg Negativity is Associated with a Higher Risk of Liver-Related Death in Patients with Chronic Hepatitis B Related Liver Cirrhosis
Journal Title: Diseases & Research - Year 2022, Vol 2, Issue 1
Abstract
Background and aims Few studies reported the association between the survival of patients with chronic hepatitis B (CHB)-related liver cirrhosis (LC) and hepatitis B e antigen (HBeAg) state. Methods Three hundred and ninety-eight CHB-LC patients from two institutions were included. To adjust for selection bias, propensity score matching (PSM) with 1:1 ratio was used to balance clinical features between HBeAg-positive and HBeAg-negative CHB-LC patients. The related factors of liver-related death were identified by cox regression analysis, while the difference of survival was analyzed using Kaplan–Meier curves. Results Two hundred and eighty-eight (72.4%) CHB-LC patients were HBeAg negative, and the median follow-up time was 33.9 months. Fifty-two liver-related deaths occurred during the follow-up period. The liver-related mortality in HBeAg-negative CHB-LC patients was comparable with HBeAg-positive patients before PSM (14.2% vs. 22.3%, P = 0.094). After PSM for age, sex, platelet count, ALT level, and HBV DNA, 77 patients were matched in each group. Higher liver-related mortality was observed in patients with HBeAg-negative CHB-LC than those of HBeAg-positive CHB-LC patients (39.6% vs. 18.7%, P = 0.019). Patients with decompensated LC had similar results. Furthermore, HBeAg-negative state was identified as a significantly risk factor of liver-related mortality (HR, 3.032; 95% CI, 1.232–7.460; P = 0.016). Conclusions HBeAg-negative state may be an independent risk factor of liver-related mortality in patients with CHB-LC.
Authors and Affiliations
Jian Wang, Shengxia Yin, Li Zhu, Jiacheng Liu, Ruifei Xue, Yu Geng, Juan Xia, Yali Xiong, Weihua Wu, Xin Tong, Xiaomin Yan, Yuxin Chen, Chuanwu Zhu, Rui Huang, Chao Wu
Keywords
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- EP ID EP740155
- DOI 10.54457/DR.202201004
- Views 58
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