HBV co-infection in HIV infected patients and its effect on progress of the disease
Journal Title: IP International Journal of Medical Microbiology and Tropical Diseases - Year 2018, Vol 4, Issue 1
Abstract
Introduction Coinfection of Human Immunodeficiency Virus HIV and Hepatitis B Virus HBV is a common event due to similar routes of transmission with significant clinical implications Progression to liver disease is more rapid in HIVHBV coinfected patients The present study was designed to find the seroprevalence of HBV in newly diagnosed HIV positive patientsMaterials and Methods 200 newly diagnosed HIV positive cases were enrolled in present study 35 cc blood was collected from these patients and HBsAg ELISA was carried out on serum obtained HBsAg positive samples were processed further to detect HBeAg and antiHBeAg by ELISA Liver Function Tests LFTs and CD4 T cell count were notedResults Out of 200 HIV positive patients 4 were coinfected with HBV Out of the 4 coinfected cases nbsp 375 were HBeAg positive and 625 were antiHBe positive None of the HIVHBV coinfected case had a CD4 Tcell count gt500 cellsmicroL whereas 552 of nbspHIV monoinfected cases had CD4 Tcell counts gt 500 cellsmicroL 375 HIVHBV coinfected cases had CD4 Tcell count le200 cellsmicroL whereas only 114 HIV monoinfected cases had CD4 Tcell count le200 cellsmicroLHIVHBV coinfected cases had more deranged liver enzymes 50 of HIVHBV coinfected cases belonged to WHO stage II whereas majority 916 of HIV monoinfected cases belonged to WHO stage IConclusion This study highlights that routine screening of HBsAg should done in all HIV infected patients and virological markers of HBV Liver Function Tests and CD4 T cell count of HIVHBV coinfected patients should be assessed for appropriate managementKeywords HIVHBV CoinfectionCorrelation CD4 Count WHO staging LFT
Authors and Affiliations
Bhagyashri R. Jadhav, Vidya P. Arjunwadkar, Renu S. Bharadwaj
Keywords
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- EP ID EP485831
- DOI 10.18231/2455-6807.2018.0005
- Views 71
- Downloads 0
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