HBV Covalently Closed Circular DNA Targeting by Plant Derived Chemical Agent Exploring the Potential of Coumarins
Journal Title: Medical Journal of Clinical Trials & Case Studies - Year 2023, Vol 7, Issue 3
Abstract
Hepatitis B virus (HBV) infection remains a global health concern, with persistent covalently closed circular DNA (cccDNA) hindering curative treatments. Coumarin is one of these natural compounds that could be utilized as a pharmaceutical agent due to its stability, solubility, availability and low toxicity. Previous studies demonstrate their efficacy, but the challenges of specificity and resistance remain unexplored. Further research is needed to unlock coumarins full potential as antiviral agents for chronic HBV infection and removal of cccDNA from infected hepatocytes.
Authors and Affiliations
Tyagi P, Saini AK and Kumar J*
Keywords
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- EP ID EP758300
- DOI 10.23880/mjccs-16000338
- Views 8
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