HBV Flare Under Tenofovir Treatment in Chronic Hepatitis B: Case Report
Journal Title: Viral Hepatitis Journal - Year 2020, Vol 26, Issue 3
Abstract
The purpose of chronic hepatitis B treatment is to stop the progression of the disease and prevent cirrhosis and liver cancer that may occur with the progression of the disease. In the current treatment, one of the nucleosis (t) id analogs, tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide fumarate and entecavir (ETV), is preferred due to its high genetic barriers. In this study; HBV flare was detected in a patient who received TDF treatment and rtN236T, sP120T and sC124R mutations were identified as a result of the resistance analysis. A logarithmic reduction in HBV-DNA level was achieved by adding ETV to the current treatment. As a result, acyclic phosphonate mutations can reduce the clinical response in the treatment of CHB with TDF. HBV drug resistance analysis should definitely be used in rational use of TDF, a potent drug, and in determining the direction in KHB treatments.
Authors and Affiliations
Müge Deniz Toygar, Murat Sayan, Sıla Akhan
Keywords
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- EP ID EP691657
- DOI 10.4274/vhd.galenos.2020.2020.0005
- Views 123
- Downloads 0
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