HEALTH CARDIOPROTECTIVE PROFILING OF SYZYGIUM CUMINI: EVIDENCE IN EXPERIMENTAL MODEL OF ISCHEMIC INJURY
Journal Title: Revista Científica Multidisciplinar Núcleo do Conhecimento - Year 8, Vol 1, Issue 07
Abstract
Syzygium cumini is a medicinal plant traditionally used to treat cardiometabolic disorders. This study proposed to evaluate the cardiopreventive effect of the hydroalcoholic extract from the S. cumini leaves (HESc) on ischemic injury isoproterenol (ISO)-induced in rats. Male albino Wistar rats (Rattus norvegicus) were pre-treated with HESc or water for 15 days. They received a challenge with ISO (85 mg/kg) on the 14th and 15th days for induction of ischemic injury. For all animals were obtained electrocardiographic parameters predictive of the lesion in addition to evaluation of troponin I changes in animals. We also realized a phytochemical screening, and in vitro antioxidant activity including 1,1-Diphenyl-2-picrylhydrazyl radical. HESc was found to be rich in flavonoids, and high antioxidant potential. Addictionaly, increased the survival rate and reversed ventricular remodeling caused by isoproterenol-induced ischemic injury in a dose-dependent manner. Inhibition of ST segment elevation, impairmentf QT interval prolongation, reduction of Troponin I levels also were observed in animals pretreated with HESc. Our results suggest that pretreatment with HESc reduces myocardial injury and simple phenols and flavonols are likely to be responsible for its effect on cardiomyocyte integrity, confirming that S. cumini is a promising plant source of bioactive compounds for the treatment of ischemic syndromes.
Authors and Affiliations
Rachel M. Ribeiro | Federal University of Maranhão (UFMA), Federal Institute of Maranhão (IFMA), State University of Maranhão (UEMA)
Keywords
Related Articles
- EP ID EP720112
- DOI 10.32749/nucleodoconhecimento.com.br/health/cardioprotective
- Views 29
- Downloads 0
CASES REPORTS APPLYING VASCULAR SYSTEMIC PHOTOBIOMODULATION TREATMENT
The systemic effects of lasers have been observed for a long time. Despite a huge amount of evidence, its foundations are still being systematically investigated with several scientific experiments. As the metabolism in...
MORPHOLOGY OF THE BIFID XIPHOID PROCESS OR FORAMEN: IS THERE A DIFFERENCE IN CADAVER OR IMAGING?
Context: Anatomical variations of the sternum are frequent, in particular, the occurrence of foramina and divisions of the xiphoid process. The authors have used means of investigation ranging from dissection to imaging...
THE EVOLUTION OF THE JUDICIAL RECOVERY INSTITUTE: AN ANALYSIS OF IMPACTS AFTER THE COVID-19 PANDEMIC
The main objective of this article is to present the relationship between the judicial recovery institute and the consequences generated by the COVID-19 pandemic. The development of this study was carried out from the pe...
INDIGENOUS ETHNOKNOWLEDGE ABOUT STINGLESS BEES (APIDAE: MELIPONINI) IN THE BRAZILIAN TERRITORY: BIBLIOMETRICS
This study aimed to analyze the characteristics of scientific productions that address the knowledge of indigenous peoples about stingless bees in different ethnicities, in the Brazilian territory, through bibliometric a...
REASONABLE DURATION OF THE TAX PROCESS
This article aims to see the role of the principle of reasonable duration of the process in the constitutional and procedural tax scope, as well as its interconnection with the field of Human Rights. The principle of rea...