Heart Rate and QT interval Variability in Multiple Sclerosis: Evidence for Decreased Sympathetic Activity
Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 4
Abstract
Decreased beat-to-beat heart rate variability (HR) and increased beat-to-beat QT interval variability are associated with significant cardiovascular mortality. The aim of this study was to compare beat-to-beat HR and QT variability among patients with multiple sclerosis (MS) and normal controls to investigate cardiac autonomic function. We investigated spectral measures of HR and QT interval variability in 13 patients with MS and 16 normal controls during sleep. Our results showed modest but significant decreases in HR total power (TP: 0-0.5 Hz), VLF power (very low frequency power: 0-0.04 Hz) and LF power (low frequency: 0.14-0.5 Hz) in patients with MS compared to normal controls. QT interval TP, VLF, LF and HF powers were all highly significantly lower (p
Authors and Affiliations
Micahel BONNETT, Janet MULCARE, Thomas MATHEWS, Satyendra GUPTA, Nizam AHMED, Vikram YERAGANI
Keywords
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