Abstract

Abstract: Objective: To evaluate the influence of parental diabetes on the heart rate variability of their non diabetic off springs. Method: The study was conducted in the department of Physiology SSIMS and RC after the approval of the institutional ethical committee. Thirty cases in the age group of 18 -25 years, who were non diabetic off springs of diabetic parents and age and gender matched thirty subjects with no family history of diabetes mellitus were recruited as controls for the study on the basis of predetermined inclusion exclusion criteria. Resting 15 minutes lead II ECG and heart rate was recorded by AD Instruments - Power lab 26T, Australia. Offline assessment of time and frequency domain parameters of heart rate variability (HRV) was done with Lab Chart 7 software. Result: Frequency domain analysis of HRV shows increased low frequency (p value 0.01) and a decreased high frequency (p value 0.02) in the cases as compared to that in the control group and the difference is statistically significant. Time domain analysis shows decrease in SDNN (standard deviation of normal R-R interval). Conclusion: Our results suggest that the autonomic functions of subjects whose parents are diabetic are affected and show a sympathetic over activity.

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