Helical tomotherapy for advanced esophageal cancer improves target conformity and homogeneity: A comparison with fixed-field intensity-modulated radiotherapy
Journal Title: JOURNAL OF ADVANCES IN PHYSICS - Year 0, Vol 11, Issue 3
Abstract
Purpose: To evaluate the usefulness of helical tomotherapy (HT) in the treatment of advanced esophageal cancer (EC) and compare target homogeneity, conformity and normal tissue doses between HT and fixed-field intensity-modulated radiotherapy (ff-IMRT). Methods: In all, 23 patients with cT3-4N0-1M0-1a thoracic EC (upper esophagus, 9 patients; middle esophagus, 6; distal esophagus, 6 and esophagogastric junction, 2) who were treated with ff-IMRT (60 Gy in 30 fractions) were re-planned for HT and ff-IMRT with the same clinical requireÂments. Comparisons were performed using the Wilcoxon matched-pair signed-rank test. Results: Compared with ff-IMRT, HT significantly reduced the homogeneity index for thoracic, upper, middle and distal ECs by 38%, 31%, 36% and 33%, respectively (P < 0.05). The conformity index was increased by HT for thoracic, upper and middle ECs by 9%, 9% and 18%, respectively (P < 0.05). Target coverage was improved by 1% with HT (P < 0.05). The mean lung dose was significantly reduced by HT for thoracic and upper ECs (P < 0.05). The V20 (volume receiving at least 20 Gy) and higher dose volumes of the lungs were decreased by HT in all cases, but the differences were significant for thoracic, upper and distal ECs (P < 0.05), with reductions of 2.1%, 3.1% and 2.2%, respectively. HT resulted in a larger lung V5 for thoracic, upper, middle and distal ECs, with increases of 3.5%, 1.5%, 7.2% and 3.2%, respectively. Heart sparing was significantly better with HT than with ff-IMRT in terms of the V30 and V40 for thoracic, upper, middle and distal ECs (P < 0.05). Conclusions: Compared to ff-IMRT, HT provides superior target coverage, conformity and homogeneity, with reduced the volume of high doses to the lungs and heart for advanced EC. HT may be a treatment option for advanced EC, especially upper EC.
Authors and Affiliations
Luhua Wang
Keywords
Related Articles
- EP ID EP653685
- DOI 10.24297/jap.v11i3.471
- Views 55
- Downloads 0
Boson peak and nanostructure of chalcogenide glass-like semiconductors
The structural features of As2Se3, As40Se30S30, As40Se30Te30, As33.3Se33.3S33.4, As33.3Se33.3Te33.4 chalcogenide glasses have been studied by Raman spectroscopy in low-energy region. The results are explained in view of...
Red Sunrise, Blue Sky, and Red Sunset: the Light Refraction of Earth Atmosphere
The red sunrise, red sunset, and blue sky were common nature phenomena. Why sunrise and sunset are red color, and why daytime sky is blue? This paper used earth atmosphere refraction principles to explain the sky and sun...
OPTICAL BAND GAP ANALYSIS OF NANO-CRYSTALLINE CERAMIC PbSrCaCuO
ABSTRACTNano-crystalline Ceramic PbSrCaCuO have been prepared by a high-energy ball milling process through mechanically assisted synthesis. The prepared sample was then subjected to calcinations to acquire the desired h...
Theory Behind Formation of Neutrino and Procedure of Calculating Mass of Neutrino Under Various Circumstances
Study of neutrino is very important aspect of particle physics. Neutrino has unique characteristics like zero charge and negligible mass compared to other subatomic particles which makes extremely difficult to analyse an...
Preparation and Characterization of Silver and Gold Nanoparticles and Study Influence on Physical Properties of PVA/PVP nanocomposites
Gold nanoparticles (Au NPs) and Silver nanoparticles (Ag NPs) ware prepared by green synthesis extraction using the Chenopodium murale leaf extract, the obtained (Ag NPs and Au NPs) were investigated by UV/Vis. absorpti...