Helicobacter pylori as a risk indicator of oral Squamous cell carcinoma – A PCR based study
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2016, Vol 8, Issue 7
Abstract
Traditionally oral cancer has always been associated with tobacco and areca nut chewing habit. An emerging concept is that tumor development and progression is also largely dependent on the cross - talk between immune system and tumor cells. Amongst internal agents, tumor associated macrophages and fibroblasts, play a pivotal role. Cytokines released by fibroblasts crucially affect the carcinoma cell behaviour and the role of chronic inflammation in tumor progression has now widely accepted. Amongst external agents causing infections like, fungal agents (candidiasis) and viruses (HPV and EBV), with oral cancer have already been discussed by many researchers. It is the bacterial population (H. pylori) in microenvironment, which is now continuously increasing the concern of the scientists towards itself. H. pylori association has already been established with gastric, pancreatic and hepatocellular cancers. It is present in oral cavity with GCF and plaque as its ecological niche and is shown to release inflammatory mediators like cytokines, when associated with chronic gingivitis and periodontitis. These inflammatory mediators when accumulate in the microenvironment of tissues for prolonged periods of time have the capacity to induce cell proliferation and to promote prolonged cell survival through activation of oncogenes and inactivation of tumor suppressor genes. This results in genetic instability with increased risk of oral cancer. Association of H. pylori is still a grey area of study as not many studies have been done in respect to the same. Hence, this study is done to outline the association between H. pylori, its role in chronic inflammation and finally the progression of the disease towards oral cancer.
Authors and Affiliations
Dr. Archana A. Gupta, Dr Supriya Kheur, Dr. Mamatha, G. S. , Dr. Lakshmi Shetty, Dr. Mohit Kheur
Keywords
Related Articles
- EP ID EP404980
- DOI -
- Views 100
- Downloads 0
Clinical study of heart disease complicating pregnancy in a tertiary Care centre
Heart disease complicating pregnancy is considered as a high risk situation. Increased cardiac demands during the course of pregnancy potentially increase morbidity and mortality in women with underlying heart disease. R...
A COMPARATIVE EVALUATION BETWEEN SNORERS AND NON SNORERS USING EPHALOMETRIC ANALYSIS OF SOFT TISSUES
Introduction: Sleep-disordered breathing (SDB) is a collective clinical term encompassing primary snoring, upper airway resistance syndrome (UARS), and obstructive sleep apnea (OSA). These syndromes currently are regarde...
A rare case of aneurysmal bone cyst of the calcaneum
Aneurysmal bone cyst (ABC) is a benign solitary bone lesion of unknown etiology. ABCs mainly occur in the long bones but only rarely in the bones of the feet. Few cases of ABC involving the calcaneum have been reported.W...
Issues in global maternal health - trends in the management of pre-eclampsia; a systematic review of the literature
Aims: Pre-eclampsia (systolic blood pressure of >140 mmHg and diastolic blood pressure >90 mmHg) is a fundamentally unique condition, occurring in the post-partum as well as the pre-natal period of pregnancy. It is a pro...
A systematic review of analysis of fracture patterns in maxillofacial assault related injuries in the indian sub-continent and south-east asia
Maxillofacial assault related injuries are an etiological important factor in fracture of facial bones. Here we have carried out a systematic review of analysis of fracture patterns in maxillofacial assault related injur...