Helicobacter Pylori Cytotoxin-Associated Gene A -Seropositivity in Type 2 Diabetic Patients; Relation to Moderately Increased Albuminuria and Inflammatory Markers
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 6
Abstract
Background and Aim: The pathogenesis of moderately increased albuminuria (Malb) in type 2 diabetic patients is still unclear. Infection with Helicobacter pylori (H. pylori), especially with strains carrying the cytotoxin-associated gene A (CagA), might play a role. In this study, we investigated the possible association between H. pylori CagA-seropositivity in type 2 diabetic patients and Malb as well as increased inflammatory markers. Subjects and Methods: Ninety type 2 diabetic patients with Malb were included in the study. These patients were divided into two groups as H. pylori seropositive (35 patients) or seronegative (55 patients). In the 2 groups, level of urine albumin creatinine ratio (UACR), inflammatory markers (CRP, ESR), glycemic control indices (fasting blood glucose, HbA1c) and other parameters were compared. Results: There was a significant progressive increase in UACR mean values and thus in Malb comparing H. pylori CagA seropositive and seronegative group (p = <0.001). Malb has significant positive correlation with anti-CagA IgG titer (r=0.497, p<0.001). CagA seropositive patients had significantly higher inflammatory markers (CRP, ESR), p value <0.001. They also showed a significantly poor glycemic control (p = <0.001) and higher lipid profile than the seronegative group. Conclusions: H. pylori CagA antibodies per se may play a role in the pathogenesis of Malb and increased inflammatory response in type 2 diabetic patients. Thus it may play an important role in the development or progression of diabetic nephropathy
Authors and Affiliations
Marwa Ahmed Meheissen
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