HEMATOLOGICAL AND BLOOD-BIOCHEMISTRY PARAMETERS OF GUINEA FOWLS IN EARLY STAGE OF NITROSODIETHYLAMINE INDUCED HEPATOCARCINOGENESIS

Journal Title: TRADITION AND MODERNITY IN VETERINARY MEDICINE - Year 2017, Vol 2, Issue 2

Abstract

In ovo models (avian embryos) are a novel alternative to laboratory animals used in the experimental cancer research. In the present study, the preneoplastic liver lesions induced by N-nitrosodiethylamine in guinea fowls were examined by histopatological methods. The alterations of some hematological and biochemical parameters were examined in guinea fowls hatched from carcinogen-inoculated eggs. Histopathology confirmed the presence of basophilic and eosinophilic foci of altered hepatocytes, strongly resembling the morphology of the preneoplastic lesions previously found in other avian species and laboratory rodents treated with the same carcinogen, as well as in humans with hepatocellular carcinomas. In addition to the focal hepatic lesions, pronounced hyperplasia of cholangiocytes and spongiosis hepatis were also detected in treated guinea fowls. The established alterations of hematological and biochemical parameters included thrombocytopenia and an increase of the levels of major liver enzymes and were related to the hepatocarcinogenesis. In addition, changes in the leukogram (leukocytosis, lymphocytosis and granulocytosis), as well as hypoproteinemia, hypoalbuminemia and hypoglycemia were observed.

Authors and Affiliations

Branimir Nikolov, Vasil Manov, Roman Pepovich, Tanzhu Mehmedov, Kalin Hristov, Krasimira Genova, Elena Nikolova, Reneta Petrova, Ani Georgieva, Anton Kril

Keywords

Related Articles

OFFER AND DEMAND OF GOAT’S MILK PRODUCTS IN PELAGONIA REGION R. MACEDONIA

Goat breeding in the Republic of Macedonia is a sector of husbandry industry that has a good basis for improving the genetic capacity of livestock breeding, increasing the volume of production and creating opportunity fo...

QUALITY AND SAFETY OF FEED USED IN FEEDING CATTLE

This article addresses issues related to the quality and safety of feed and additives used in the feeding ofcattle. The indicators characterizing the quality of feed – dry matter, energy, crude protein, digestible protei...

BIOACCUMULATION OF METALS IN TISSUES AND HELMINTHS OF HARES IN KARDZHALI REGION

This study was aimed to evaluate content of heavy metals in Lepus europeas Pallas 1778 and its helminth Trichuris sylvilagi (Nematoda) in Kardzhali region, Bulgaria. The contents of Cd, Pb, Zn, Mo, Mn, and Co were determ...

A CASE REPORT OF ECLAMPSY IN DOG

Eclampsia known as puerperal tetany is an acute, life-threatening disease caused by low blood calciumlevels (hypocalcemia) in dogs, during pregnancy and the first weeks of lactation after giving birth. Etiology ispoor nu...

SURGICAL EXTRACTION OF ADULT FORMS OF DIROFILARIA IMMITIS IN DOG. A PILOT STUDY

In recent years, recorded cases of dirofilariasis in dogs have increased significantly in our country. The IDEXX 4Dx Snap test was positive for dirofilariasis. The operation was performed in a dog, male, mixed breed, 8 y...

Download PDF file
  • EP ID EP234866
  • DOI -
  • Views 118
  • Downloads 0

How To Cite

Branimir Nikolov, Vasil Manov, Roman Pepovich, Tanzhu Mehmedov, Kalin Hristov, Krasimira Genova, Elena Nikolova, Reneta Petrova, Ani Georgieva, Anton Kril (2017). HEMATOLOGICAL AND BLOOD-BIOCHEMISTRY PARAMETERS OF GUINEA FOWLS IN EARLY STAGE OF NITROSODIETHYLAMINE INDUCED HEPATOCARCINOGENESIS. TRADITION AND MODERNITY IN VETERINARY MEDICINE, 2(2), 27-32. https://europub.co.uk/articles/-A-234866