Hematological and Bone Marrow Biopsy Evaluation in Non Hodgkin Lymphoma
Journal Title: International Journal of Current Research and Review - Year 2017, Vol 9, Issue 3
Abstract
Aim: Bone marrow evaluationis an integral part of staging workup in patients with Non-Hodgkin’s lymphoma (NHL). Aim of this study is to analyze incidence and histological pattern of bone marrow involvement in diagnosed cases of NHL. Methodology: This is a retrospective study on 85 patients diagnosed with NHL. Bone marrow biopsy was performed under local anesthesia as a part of staging workup in cases of NHL. Complete blood counts (CBC) were also noted in each case. Results: In this study, NHL cases comprised of low grade NHL 68.2%, intermediate grade 28.2% and high grade 3.5%. The age ranged from 10 to 75 years and M: F ratio was 1.07:1. 38.8% (33/85) cases showed bone marrow involvement. Majority of bone marrow involvement was seen in indolent lymphomas (87.8%). Most common pattern of involvement was mixed (12/33) followed by diffuse (9/33), interstitial (8/33) and nodular (4/33). 87.9% cases showed increase in reticulin which included reticulin grade 1(9/33), grade 2(14/33) and grade 3(6/33). Only 48.5% cases of bone marrow involved cases had CBC abnormalities while 51.5% were completely normal. CBC abnormalities included anemia (5/16), leucopenia (3/16), leukocytosis (8/16) and thrombocytopenia (9/16). Discussion: In the present study, bone marrow involvement by non-Hodgkin lymphoma was seen in 38.8% cases. Other studies also described the incidence of bone marrow involvement from 27.6% to 53%. Predominant involvement was observed in indolent cases which were similarly noted in other studies. Conclusion: Bone marrow biopsy is an essential part of staging work up of NHL affecting the prognosis and treatment.
Authors and Affiliations
Kanwalpreet Kaur Kaur
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