HEMATOLOGICAL CHANGES IN PRE AND POST HEMODIALYSIS IN PATIENTS WITH CHRONIC RENAL FAILURE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 25
Abstract
BACKGROUND CKD is a major problem worldwide, which is growing rapidly. It is the major cause of morbidity and mortality throughout the world. RBC count, Hb, hematocrit, platelet and TLC got decreased in chronic renal failure patients in many studies. Hemodialysis increases red blood cell count (RBC), hemoglobin (Hb) and packed cell volume (PCV) according to a study done to find out the effects of hemodialysis. In present study, the hematological parameters before and after hemodialysis will be observed and analyzed in CKD patients. MATERIALS AND METHODS This study was done on patients suffering from chronic renal failure admitted in hemodialysis unit at B.L.D.E. University’s Shri BM Patil Medical College, Hospital and Research Centre, Vijayapura from 1 st December, 2015 to 30th June, 2017. Under aseptic precautions, two milliliters of venous blood was taken from renal failure patients before and after hemodilaysis in an ethylene diamine tetra acetic acid (EDTA) vacutainer and immediately analyzed for a complete hemogram, including Hb, RBC count, and RDW, using an automated hematology analyzer. A peripheral smear was prepared from the same sample. RESULTS A total of 80 patients suffering from chronic renal failure were included in this study. Out of 80 patients of CRF, 58 patients (72.5%) were male and 22 patients (27.5%) were female. Maximum number of patients i.e. 25 were in age group of 51- 60 years (31.3%). In our study, Hb level was found to be increased after hemodialysis as compared to pre- dialysis. Mean Hb value in pre- dialysis patients was 7.69 ± 1.95 whereas in post dialysis patients, it was 8.46 ± 2.87 with a significant p value of 0.004. WBC level was found to be increased after dialysis when compared to pre- dialysis patients. Mean WBC value in pre- dialysis patients was 8 ± 5.31 whereas in post dialysis patients, it was 9.57 ± 6.70 with a significant p value of 0.005. Platelets were found to be decreased after dialysis as compared to pre- dialysis. Mean platelet value before dialysis was 2.10 ± 0.78 where as it was 1.87 ± 0.69 in post dialysis cases with a significant p value of 0.022. HCT level after dialysis was increased when compared to predialysis cases. Mean value of HCT before dialysis was 25.21 ± 6.49 whereas after dialysis it was 26.94 ± 7.10 with a significant p value of 0.038. NCNC anemia was most commonly seen both in pre- and post-dialysis cases. CONCLUSION Most of the hematological parameters like Hb, WBC, MCH, MCHC and HCT increased after HD as compared to predialysis cases. Platelet count was found to be decreased after dialysis as compared to predialysis cases. So, to evaluate the effectiveness of hemodialysis, it is necessary to test the complete hemogram before and after HD.
Authors and Affiliations
Ravi Gautam, Prakash M Patil
Keywords
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- EP ID EP567059
- DOI 10.18410/jebmh/2018/399
- Views 77
- Downloads 0
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