Hemoglobin Electrophoretic Patterns in Punjabi Children With Anemia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Context: Carrier frequency of hemoglobinopathy ranges from 3-17% in Indian population. Early and accurate diagnosis of type of anemia is imperative and requires the use of hemoglobin electrophoresis. Aims: To find the prevalence of hemoglobinopathy and different electrophoretic patterns in Punjabi population in subset of anemic children aged less than 18 years, by using agar gel hemoglobin electrophoresis method. Methods and Material: A prospective study included 100 Punjabi children aged <18 years with hemoglobin <9gm%. Complete hemogram, red blood cell (RBC) indices and peripheral blood film (PBF) was examined. Hemoglobin electrophoresis was performed using agar gel electrophoresis method to find different electrophoretic patterns of hemoglobin in the study group. Results: 100 cases were included with mean age (7.4±5.6years) and mean hemoglobin (7.4±1.4g/dl). Hemoglobin electrophoresis revealed abnormal hemoglobin electrophoretic pattern in five patients. Three patients had an abnormal HbA2 band (beta thalassemia trait); one patient had abnormal HbF and HbA band (beta thalassemia major); and one patient had an abnormal band in HbSD region (HbS confirmed by sickling). No statistically significant difference was noted in RBC indices, PBF examination in patients with normal versus abnormal hemoglobin pattern. Conclusions: Blood parameters including RBC indices and PBF cannot help diagnose abnormal hemoglobin pattern. Hemoglobin electrophoresis by agar gel electrophoresis method is a cost effective method for screening patients with suspected hemoglobinopathies, however it is time consuming and requires proper standardization.
Authors and Affiliations
Kaur Puneet, Singh Daljit, Kukreja Sahiba, Manjari Mridu
Keywords
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- EP ID EP598042
- DOI 10.9790/0853-1605096468.
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