Hemolytic transfusion reaction analysis and domestic literature review
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 4
Abstract
Objective To investigate the causes of hemolytic transfusion reaction (HTR), identify clinical symptoms and severity, explore clinical detection methods, so as to provide reference for safe and rational blood use. Methods Clinical data of 3 cases of HTR in our hospital were analyzed. Blood type, unexpected antibody screening, antibody identification by serological method and elution test were reexamined in laboratory, and domestic literatures of HTR were reviewed. Results Case 1, 2, and 3 were diagnosed as DHTR (with anti-JKa antibody identified 7 days after transfusion), AHTR (with anti-Ce and anti-JKb antibodies respectively detected 5 and 7 days after transfusion) and HTR of unknown type (with anti-E antibody detected 3 days after transfusion). A total of 33 cases of HTR were reported from 2005 to 2021 in China, including 14 cases of AHTR, 18 cases of DHTR and 1 case as unknown type. The causes of HTR in 33 cases were as follows: ABO system antibodies in 4 cases, Rh system antibodies in 17 cases, 4 Kidd system antibodies in 4 cases, non-immune factors in 3 cases, and without antibody specificity in 5 cases. Conclusion Since various blood system antibodies may cause hemolysis reaction, it is of great significance to clarify the causes and identify the alloantibody for the safe use of blood in clinical practice.
Authors and Affiliations
Xinxin HAO, Qiushi WANG
Keywords
Related Articles
- EP ID EP738530
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.04.010
- Views 40
- Downloads 0
Severity and multiple indexes of jaundice in ABO hemolytic disease of fetus and newborn: a comparative analysis
Objective To explore the correlation between the severity of jaundice in ABO hemolytic disease of fetus and newborn (HDFN) and multiple indicators, in order to achieve accurate diagnosis, timely treatment, and prevent co...
Quality of medicinal maltose as a excipient in the production of blood products: a comparative study
Objective To comprehensively compare the quality and filtration efficiency of medicinal maltose between two domestic manufacturers(B, C) and one foreign manufacturer(A), compare their product quality as an excipient for...
Correlation of D-dimer, serum potassium and thromboelasto-graphy parameters with progressive hemorrhagic injury
Objective To investigate the correlation between D-dimer, serum potassium and thromboelastography parameters and progressive hemorrhagic injury (PHI) after brain injury. Methods The data of 209 patients with traumatic br...
Exploring the risk factors of blood transfusion in patients with isolated traumatic brain injury based on machine learning prediction models
[Objective] To explore the risk factors of blood transfusion in patients with isolated traumatic brain injury (iTBI) based on multiple machine learning methods, so as to establish a predictive model to provide reasonable...
Progress in clinical researches of platelet-rich plasma in the treatment of chronic refractory wounds
Cutaneous chronic wounds are a major global health burden in continuous growth due to population aging and the higher incidence of chronic diseases, such as diabetes. In the process of spontaneous wound healing, growth f...