Hemophagocytic syndrome secondary to Plasmodium vivax infection - A prospective study of 11 cases
Journal Title: Asian Pacific Journal of Health Sciences - Year 2018, Vol 5, Issue 1
Abstract
Background: Hemophagocytic syndrome is a reactive disorder of the mononuclear phagocytic system. The association of pancytopenia in severe malaria due to Plasmodium vivax with hemophagocytic syndrome is extremely rare and very few cases are reported in the world literature. Aim: The study was undertaken to establish P. vivax infestation associated with hemophagocytosis in bone marrow as one of the causes of chronic pancytopenia/bicytopenia with fever and splenomegaly in endemic areas. Materials and Methods: Prospective study of 110 patients of different age groups presenting with chronic fever with pancytopenia or bicytopenia from January 2015 to November 2017 was carried out. 49 patients showed the presence of P. vivax trophozoites in bone marrow. Among these 11 patients showed the presence of hemophagocytosis in bone marrow fulfilling 6 out of 8 criteria of diagnosing hemophagocytic lymphohistiocytosis according to 2004 criteria. Results: The age of patients varied from 8 years to 54 years. 11 Cases showed the presence of P. vivax trophozoites with the presence of hemophagocytosis in bone marrow showing, hyperplastic marrow showing normoblastic and megaloblastic hyperplasia. Conclusion: Hemophagocytic syndrome in malaria should be suspected in all cases of chronic fever with pancytopenia or bicytopenia, splenomegaly. Bone marrow aspiration is recommended to confirm the diagnosis of P. vivax as one of the causes of the secondary hemophagocytic syndrome in malaria-endemic areas.
Authors and Affiliations
nupur rastogi
Keywords
Related Articles
- EP ID EP517781
- DOI 10.21276/apjhs.2018.5.1.7
- Views 211
- Downloads 0
A Clinicopathological study of skin and adnexal neoplasms at a rural based tertiary teaching hospital
Skin and adnexal tumors (SATs) are those neoplasms that differentiate toward or arise from pilosebaceous unit, eccrine sweat glands or apocrine sweat glands, and these tumors are classified into four groups that exhibit...
Histopathological spectrum of meningioma and its variants
Background: Meningiomas are tumors that arise from the lepto meningeal covering of brain and spinal cord, accounting for upto 34% of all CNS tumors. Mostly meningiomas are slow growing and are generally considered benign...
The study of functional outcome of distal end femur fractures operated with locking compression plate
30 patients with closed fracture lower end of femur were studied. The method used for fracture fixation was closed or open reduction and internal fixation with locking compression plate. The duration of follow up ranged...
A study on awareness of Dental students in Electronic Waste Management
Background: Electronic Waste or e-waste is one of the rapidly growing problems in the world. The old electronic appliances such as computers, laptops, TVs, DVD players and mobile phones etc which have disposed by their u...
Eclampsia-prevalent yet preventable complication – experience at tertiary care centre
Introduction: Maternal mortality is not only a health disadvantage, rather it is a social disadvantage as it puts economic burden on the family, community, governments, and nations. Aim: It is prospective study of eclamp...