Hemophilia A and Induced Pluripotent Stem Cells
Journal Title: Journal of Advances in Biology & Biotechnology - Year 2017, Vol 14, Issue 3
Abstract
Hemophilia A is a hemorrhage disorder inherited according to the X-linked inheritance pattern. It affects about 1 in 4,000 to 10,000 males. Permanent changes in the F8 gene result in hemophilia A. These changes result in an abnormal version of coagulation factor VIII. This abnormal condition determines the kinds of the disorder, namely, severe and mild or moderate hemophilia A. Currently, to treat hemophilia A, infusions of plasma-derived or recombinant factor VIII can be used. However, the cost is extremely high. It makes heavy burdens on the patients, their families or the health care system. Therefore, advanced therapy as iPSCs technique has attracted attention of researchers to research for curing this disorder. For example, to obtain edited DNA segments due to hemophilia A, this technique can be used. Research results in animal models have shown important advances.
Authors and Affiliations
Martin L. Nelwan
Effect of Earthworm (Perionyx excavatus) Powder on Selected Bacteria and Fungi
Aims: Investigations were carried out at University of Guyana Turkeyen Campus during the year 2014-15 and focused on the chemical composition of earthworm (Perionyx excavatus) powder and its effect on microbes. Study De...
PDMS Flow Cell for Monitoring Bacterial Adhesion Capacity of Escherichia coli O157:H7 in Beverages
Aims: To develop and standardize a polydimethylsiloxane (PDMS) flow cells for monitoring bacterial adhesion capacity of biofilm formation by Escherichia coli O157:H7 in Beverages industry. Study Design: PDMS chip was fa...
Molecular Characterization of Common Bean (Phaseolus vulgaris L.) Genotypes Using Microsatellite Markers
Common bean (Phaseolus vulgaris) is one of the most important legume crops, but the knowledge on genetic diversity of the genotypes grown in Kenya is limited. The objective of this study was to determine the genetic dive...
Evaluation of Ready-to-eat Polyethylene Packed Pawpaw (Carica papaya) for the Presence of Antibiotic Resistant Escherichia species
Aims: The study examined ready-to-eat cut polyethylene packed pawpaw (Carica papaya) sold in the University of Port Harcourt community for the presence of antibiotic resistant Escherichia species. Study Design: The samp...
Isolation and Identification of Pediococcus pentosaceus from Cow’s Milk Curd and Its Use in Grape Juices Fermentation
Aims: The study affirms the quality of fermented grape juices with the potential probiotic bacterium Pediococcus pentosaceus, which can perhaps be used in the preparation of probioticated grape juices. Study Design: Pot...