Hemostasis in HIV Infected Individuals
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 8
Abstract
With the introduction of cART, HIV infection is slowly evolving into a chronic disease. HIV-related thrombocytopenia is the most common hemostaticdisorder. In addition, there are some abnormalities in the fluid phase of the coagulation cascade which can produce bleeding or thrombosis in the HIV patient. The most common are thrombocytopenia, prolonged prothrombin time, prolonged partially activated thromboplastin time, the production of a lupus anticoagulant and anticardiolipin antibodies, and several abnormalities in the natural-occurring anticoagulants. The thrombotic thrombocytopenic purpura (TTP) recently associated with HIV has a clinical presentation and treatment alternatives that closely resemble those for the classical disease. This study was conducted to know the pattern of these hemostatic abnormalities among PLHA’s. Our study showed most of hemostatic abnormalities occurred with advanced stage of disease which was stastistically significant too. Several thrombotic events were noted in the form of ischemic stroke and DVT, but no clinically significant bleeding manifestations. The knowledge of these hemostatic abnormalities and its early identification in the HIV seropositive patient allows a more rational care of these patients.
Authors and Affiliations
Dr. V. P. Youmash
Keywords
Related Articles
- EP ID EP519506
- DOI -
- Views 48
- Downloads 0
Comparative Evaluation of the Effect of Vitamin D Supplementation in Pregnancy and its Correlation with Fetomaternal Outcome
Introduction: Vitamin D deficiency is a common and increasing problem and concerns have been raised that there may be an epidemic of such deficiency in pregnancy. Vitamin D may be important in the pathogenesis of severe...
A Case Report of Eclampsia Predisposing to Pres: (Posterior Reversible Encephalopathy Syndrome)
Background: Posterior reversible encephalopathy syndrome or reversible posterior leukoencephalopathy syndrome presents with headache, seizures, altered consciousness and visual disturbances associated with conditions lik...
A Comparative Study between Efficacies of Povidone-Iodine (10%) Solution Versus Alcohol Based Solution Hygienium as Skin Antiseptic
Background and Objectives: Skin asepsis is a crucial measure for preventing infectious complications of central neuraxial block, i.e. meninigitis. The aim of this study was to comparative evaluatation of effectiveness of...
Septo-Optic Dysplasia: A Case Report
Septo-optic dysplasia also referred to as de Morsier syndrome and is a disorder of early brain development. Three characteristic features are under development (hypoplasia) of the optic nerve, abnormal formation of struc...
Malignant Brenner Tumour – A Rare Entity
Malignant Brrenner Tumour of ovary is an extremely rare tumour that morphologically resembles Urothelium. Most Brenner tumours are benign with only 2-5% being malignant. Here we present a case of 42 year old women with a...