Hemostatic Effect of Ethanol Extract of Piper betle, Linn Leaves to Male Mice
Journal Title: Molekul - Year 2017, Vol 12, Issue 1
Abstract
Hemorrhage occurs in most of the dental care. Untreated hemorrhage could cause excessive blood loss, hypotension, and cyanosis. A Natural resource that reported has an hemostatic effect is ethanol extract of betel leaves (Piper betel, Linn).The aim of this study is to find the minimum concentration of ethanol extract of betel leaves which capable of shortening the bleeding time in mice. The experimental study used pretest-posttest with control group design was conducted on 35 mice that divided into 7 group which are negative control, positive control (feracrylum 1%), the ethanol extract of betel leaves 1%, 5%, 10%, 15%, and 20%. All mice were injected heparin intravenously. Miceâs tail was cut at diameter 3 mm and pretest bleeding time was counted. Miceâs tail was recut at diameter 4 mm, given treatment for 5 seconds and posttest bleeding time was counted. Results of paired t-test showed that reduction of bleeding time between pretest and posttest was significant (p<0,050). The enhancement of ethanol extract of betel leaves concentration leads to better hemostatic effect. Results of ANOVA test showed that comparison of posttest bleeding time among groups was significant (p<0,050). The minimum concentration of ethanol extract of betel leaves which capable of shortening the bleeding time in mice is 5%.
Authors and Affiliations
Sadakata Sinulingga, Subandrate Subandrate, Bebbi Arisya Kesumaputri, Galuh Anggraini
Keywords
Related Articles
- EP ID EP609175
- DOI 10.20884/1.jm.2017.12.1.264
- Views 95
- Downloads 0
Validation Method of Flame-AAS with Microwave Digestion for Mineral Analysis in Carbohydrate-Rich Samples
One of the effective methods for mineral destruction is by using microwave digestion. However, some parameters in the microwave manual book are different with AOAC method such as the volume of acid, temperature, and the...
Degradation of Paraquat in Gramoxone Pesticide with Addition of ZnO
Paraquat is the most toxic herbicide, the main agricultural crops and plantations that use them are cloves, cocoa, oil palm, rubber, coffee, and pepper. Therefore, it is necessary to study to degrade paraquat compounds b...
Antioxidant Potential Of Lansium Domesticum Corr. Seed Extract In White Male Rat (Rattus Novergicus) Induced By Alcohol
Lansium domesticum Corr. is a typical plant of Indonesia. The seeds have a lot of useful compounds, such as flavonoids. Flavonoids are a natural compound that can act as antioxidants. The aim of this study was to determi...
STUDY ON THE FENTON REACTION FOR DEGRADATION OF REMAZOL RED B IN TEXTILE WASTE INDUSTRY
Remazol Red B is a reactive dye that is often used in the textile industry. The dye can cause serious problems in the environmental / water because it is difficult to be degraded by microorganisms. Decolorization of reac...
Evaluation of Free Radical Scavenging Activity in Ethanolic Extract from Promising Accessions of Curcuma aeruginosa RoxB.
This study evaluated the free radical scavenging activity in ethanolic extracts from 20 accessions of Curcuma aeruginosa. The radical scavenging activity of the extract accessions was investigated with 2,2-diphenyl-1-pic...