HENOCH-SCHONLEIN PURPURA - CLINICAL AND INVESTIGATIVE STUDY OF 20 PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 92
Abstract
BACKGROUND Henoch-Schonlein Purpura (HSP) is a systemic small vessel vasculitis with multiorgan involvement characterised by palpable purpura, arthritis, abdominal pain and renal disease. The aetiology and clinical features are varied but histopathology is characterised by leucocytoclasia with deposition of IgA immune complexes. Aims and Objectives- The present study was done to know the spectrum of various cutaneous manifestations, systemic involvement and aetiology of Henoch-Schonlein purpura. MATERIALS AND METHODS The study was carried out on patients who were clinically diagnosed as Henoch-Schonlein purpura fulfilling EULAR criteria, attending the Outpatient Department of Dermatology, Venereology and Leprosy, King George Hospital, affiliated to Andhra Medical College, Visakhapatnam from January 2014 to December 2015. It is a cross-sectional type of study and a total of 20 cases were studied. Inclusion Criteria- All patients attending to OPD, clinically diagnosed as Henoch-Schonlein purpura fulfilling EULAR criteria, irrespective of age and sex were included in study. Exclusion Criteria- Patients with thrombocytopenic purpura, disorders of coagulation and on warfarin/heparin treatment. RESULTS Out of 20 patients enrolled in study, most common age group is in between 0-20 years, female preponderance, all patients presented acutely with lesions less than 6 weeks duration, 60% of patients had symptoms of burning and itching in lesions, 30% had pain in lesions, 30% had history of low grade fever, 80% of patients had arthralgia, 65% had gastrointestinal symptoms, 30% had history of sore throat, none had history of significant drug exposure within 6 weeks of onset of lesions. Majority of patients had elevated ESR (70%). 30% of patients had ASO titres positive, of which only 15% had throat swab positive for beta-haemolytic streptococci, ANA titres were negative in all patients, renal involvement in the form of albuminuria was seen in 30% and haematuria in 20%. Out of 30% of patients with renal involvement only 5% had significant renal impairment with elevated blood urea and serum creatinine levels. Histopathology of all patients showed leucocytoclastic vasculitis with deposition of IgA. CONCLUSION In the present study, aetiology in most of patients is idiopathic but upper respiratory tract infection was found to be the commonest aetiology among others. So, infections like sore throat should be ruled out as prompt treatment. All presented with arthralgia but gastrointestinal tract involvement was also high with presentation as acute abdomen in one patient. Renal involvement was present in 30% but there is renal impairment in 5% of patients.
Authors and Affiliations
Padmasri Somala Y, Konakanchi Venkata Chalam, Guruprasad P, Anila Sunandini P
Keywords
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- EP ID EP279302
- DOI 10.14260/jemds/2017/1434
- Views 74
- Downloads 0
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