HEPARIN COFACTOR II AND HAEMATOLOGICAL PARAMETERS AMONG PATIENTS WITH OBSTRUCTIVE SLEEP APNOEA: A SINGLE CENTRE STUDY IN NORTH EAST MALAYSIA
Journal Title: International Journal of Medical Laboratory Research - Year 2018, Vol 3, Issue 2
Abstract
Background: Obstructive sleep apnoea (OSA) is seen among patients with various health co-morbidities. The reason of this study was to compare the haemostatic and haematological parameters between OSA patients and control group. Methods: A cross sectional comparative study was performed at a tertiary centre in Kelantan state of Malaysia. The diagnosis of OSA in all patients was confirmed by polysomnography. Laboratory parameters investigated were prothrombin time (PT), activated partial thromboplastin time (APTT), heparin cofactor (HC) II, activated protein C resistance (APC-R), von Willebrand factor (vWF) antigen, factor VIII assays, haemoglobin (Hb), haematocrit (Hct) and platelet count.. Result: A total of 14 male OSA patients and one female (n=15) with nearly age-matched 19 healthy individuals (female n=4) were recruited during seven months study period. All of them except one were overweight or obese and a few of them had other medical co-morbidities. Majority of them were already on definitive treatment for OSA. There were statistically significant mean differences in the levels of Hb, Hct, platelet count and HCII in the study group as compared with the control subjects.A low natural HCII among OSA group was recorded. These changes might render them at potential risk of chronic hypercoagulable state. Conclusions: Definitive risk of haemostatic abnormalities and outcomes of OSA patients with various medical co-morbidities should be further investigated. As OSA is an emerging disease in various developing countries, the long term related complications should be explored especially on transient or persistent haemostatic changes following treatment.
Authors and Affiliations
Mohamad Azmie Norasyikin, Abbas Ahmed Suhair, Ramli Marini, Abdullah Baharudin, Wan Abdullah Zaidah
Keywords
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