Hepatic Osteodystrophy- An overlooked complication
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Hepatic osteodystrophyis a metabolic bone disease commonly seen in patients with chronic liver disease(CLD). Osteoporosis&osteomalaciadevelops in most of the patients with advanced liver disease. Regardless of the etiology of bone disease, such patients have an increased incidence of bone pain and fractures, a majorsource of morbidity. Objectives -To study Bone mineral density (BMD) in patients of CLD and its correlation with severity of liver disease. Material and methods: A cross sectional study was conducted in 64 patients with evidence of cirrhosis of liver. Out of these, 24 patients were alcoholic, 16 and 10 patients were suffering from hepatitis B & C respectively and no etiology was found in rest 14 patients.BMD of patients was analysed at different sites by DEXA scan and the prevalence of osteopenia and osteoporosis was noted. Severity of liver disease was assessed by Child Pugh’s grading and compared with BMD. Results: BMD was lower in most of the patients of CLD. High prevalence of osteopenia & osteoporosis was observed at lumbar spine as compared to left hip, which was statistically significant in men(p< 0.001) and women(p < 0. 05) . BMD was compared among different Child Pugh’s severity grades, which showed high prevalence of osteopenia and osteoporosis in Child Pugh’s grade C.
Authors and Affiliations
Vivek Kumar, Sudhir Verma, Ganesh Seth, Nikhil P Joge, Ravi Misra
Keywords
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- EP ID EP589317
- DOI 10.9790/0853-1601055861
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