Hepatitis B Virus and Hepatitis C Virus Co-infection: An Evaluation of Eighty-Two Patients
Journal Title: Viral Hepatitis Journal - Year 2017, Vol 23, Issue 1
Abstract
Objective: In this study, we aimed to investigate the characteristics and treatment results of 82 co-infected patients with hepatitis B virus (HBV)/hepatitis C virus (HCV). Materials and Methods: Four university hospitals evaluated HBV/HCV co-infection cases retrospectively. We analyzed the epidemiological, virological, clinical, and histopathological data and the results of treatment in patients co-infected with HBV and HCV. Pegylated interferon (peg IFN) plus ribavirin treatment was given to patients with HCV dominance. The results of patients receiving different treatment for HBV were evaluated. Results: The mean age of the patients was 44.3±14.7 years and 52.4% were female. The major risk factors were dental therapy, any surgical procedure, hemodialysis, and blood transfusion. The average HCV RNA level and HBV DNA level were found to be 1.36x106±3.06x106 IU/mL, and 1.55x107±4.83x107 IU/mL, respectively. On histopathology, the mean grade of necroinflammation was found to be 4.9±2.6 while the mean stage of fibrosis was 1.7±1.5 in 39 patients. 8.5% of patients were positive for both HCV-RNA and HBV-DNA positive and in 85.7% of cases, HCV infection was found to be dominant. The rate of sustained virologic response was 70.8% in 24 patients receiving peg IFN plus ribavirin therapy. Reactivation of HBV was found in 33.3% of cases. HBV DNA was negative in all patients who received oral antiviral therapy. Conclusion: In cases where both HCV RNA and HBV DNA were positive, HCV was predominant. This is especially noticeable in hemodialysis patients.
Authors and Affiliations
Bilgehan AYGEN, Özgür GÜNAL, Orhan YILDIZ, Mustafa Kemal ÇELEN, Sıla AKHAN, Şener BARUT, Celal AYAZ
Keywords
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- EP ID EP228493
- DOI 10.4274/vhd.75768
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