HEPATO-RENAL PROTECTIVE EFFECT OF ORGANIUM MAJORANA AGAINST PARACETAMOL TOXICITY IN RATS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 11
Abstract
The present study investigated the hepato-renal effect of the Organium majorana leaves extract against the hepato-renal toxicity induced by paracetamol in female rats. Theirty five white female rats were used and divided into five groups each group contain 7 rats as a following: Group 1: Rats which served as the control was orally administered distilled water (the vehicle) for 30 consecutive days. Group 2: Rats in this group were received orally aqueous extract of organium (100 mg/kg), once daily for 30 consecutive days. Group 3: Rats in this group were received orally aqueous extract of organium (200 mg/kg), once daily for 30 consecutive days. Group 4: Rats in this group were served as paracetamol toxic control and were administered a single oral dose of paracetamol (2 g/kg), 1 h after last dose of distilled water administration. ats in this group were received orally aqueous extract of organium (200 mg/kg), once daily for 30 consecutive days followed by a single oral administration of paracetamol (2 g/kg), 1 h after the last organium dose administration. The degree of hepatoprotection was measured using liver enzymes (Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. The degree of renal protection was measured using creatinine, urea, total protein and glucose. Also, histopathological examinations of liver and kidney were done. The significantly disturbed liver and kidney functions by paracetamol toxicity were restored to nearly normal values by administration of Organium majorana extract. Also, the change in biochemical parameters in groups received orally paracetamol alone was modified towards the normal values in groups given paracetamol and Organium majorana extract. Histopathological effect of paracetamol on liver and kidney was also markedly decreased by co-administration of Organium majorana extract. Our findings concluded that Organium majorana extract possessed hepato-renal protective activity against paracetamol induced toxicity in rats and this protection may involve the reduction of oxidative stress.
Authors and Affiliations
Ahmed M. Soliman
Keywords
Related Articles
- EP ID EP669808
- DOI -
- Views 124
- Downloads 0
A CURRENT REVIEW ON AZADIRACHTA INDICA (NEEM)
Azadirachta indica (The Neem) has been known as the wonder tree for centuries in the Indian subcontinent. It has become important in the global context today because it offers answers to the major concerns facing mankind...
ANTIOXIDANTS EFFECTS IN CANCER SURVIVORS: A SHORT PERSPECTIVE
There have been intense debates on the use of antioxidants as neoadjuvant therapy or in combination with anti-cancer agents in the treatment of human malignancies. While the safety and effectiveness of commonly used diet...
APPLICATION OF THE METHOD OF THERMAL-SECURITY SURFACE-IONIZATION SPECTROSCOPY IN ANALYSIS OF ALKALOIDS OF CONIUM MACULATUM
Cicuta maculata is a species of flowering plants in the carrot family, known by several common names, including spotted water hemlock, spotted parsley, spotted cowboy and the root of suicide in the Iroquois. In this arti...
APPLICATION OF GC-MS IN DETERMINATION OF MALATHION IN ENVIRONMENTAL SAMPLES.
A sensitive gas chromatography mass spectrometry (GC-MS) method was developed for determination of malathion in water samples. In this study, determination of malathion has been carried out according to standard method f...
ON THE ISSUE OF CHOOSING THE COMPOSITION OF SOLUBLE TABLETS WITH LICORICE EXTRACT
The results of research in the field of development of instant tablets recommended for children on the basis oflicorice are presented. The main criteria for the selection of auxiliary substances were studied.