Hepatocellular Carcinoma Sub-types in North-Central Nigeria: A Histological Review of Liver Biopsies
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 12, Issue 4
Abstract
Introduction: Hepatocellular carcinoma (HCC) is the 6th most common cancer worldwide and a greater burden of this disease is born by the hepatitis B virus (HBV) endemic and resource deficient sub-Sahara Africa. This investigation was carried out to determine the pattern of hepatocellular carcinoma sub-types in north-central Nigeria. Materials and Methods: Archival formalin fixed and paraffin embedded 374 liver biopsy specimen blocks were obtained, sectioned, re-stained and examined histologically. Classification of primary liver cancers was done according to standard World Health Organisation criteria. Results: Chronic HBV infection was found in 219 (58.6%) and cirrhosis in 29 (7.8%) cases. HCC occurred in 76 (20.3%) cases with background cirrhosis in 18 (23.7%) of the HCC. The HCC subtypes found were the trabecular 54 (71.1%), acinar 10 (13.2%) and mixed trabecular and acinar 6 (7.9%), clear cell 5 (6.6%) and fibrolamellar 1 (1.3%) respectively. Conclusion: HCC is the most common histologically diagnosed primary liver cell carcinoma with the trabecular subtype as the predominant variant in Nigeria, followed by the pseudoglandular and the mixed types.
Authors and Affiliations
R. A. Vhriterhire, J. A. Ngbea, B. A. Ojo, O. O. Jegede, A. N. Manasseh, M. D. Ayuba, B. M. Mandong
Keywords
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- EP ID EP339943
- DOI 10.9734/BJMMR/2016/21772
- Views 72
- Downloads 0
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