Introduction. Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Bile duct ligated rats constitute an interesting model to study the mechanism of cholestasis, and its action on seve...
[b]Background[/b]. VCAM-1 (soluble vascular cell adhesion molecule-1) plays a role in liver angiogenesis. Hepatocellular carcinoma (HCC) has important angiogenic activity, so expression of VCAM-1 may be pathogenic. [b]Ai...
Background and aim: The pharmacokinetics of acemetacin, a non-steroidal anti-inflammatory drug which is biotransformed to indomethacin by hepatic first-pass effect, was examined during the necrotic and regeneration phase...
Methionine is an essential amino acid that is metabolized mainly by the liver where it is converted to Sadenosylmethionine (SAMe) by the enzyme methionine adenosyltransferase. Although all mammalian cells synthesize SAMe...
For the last decade, the combination therapy of pegylated interferon (Peg-IFN) plus ribavirin (RBV) hasbeen considered as the standard of care treatment for chronic hepatitis C virus (HCV) infection. However, it has been...
Bile acids content in brain of common duct ligated rats
Introduction. Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Bile duct ligated rats constitute an interesting model to study the mechanism of cholestasis, and its action on seve...
Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
[b]Background[/b]. VCAM-1 (soluble vascular cell adhesion molecule-1) plays a role in liver angiogenesis. Hepatocellular carcinoma (HCC) has important angiogenic activity, so expression of VCAM-1 may be pathogenic. [b]Ai...
Pharmacokinetics of acemetacin and its active metabolite indomethacin in rats during acute hepatic damage and liver regeneration
Background and aim: The pharmacokinetics of acemetacin, a non-steroidal anti-inflammatory drug which is biotransformed to indomethacin by hepatic first-pass effect, was examined during the necrotic and regeneration phase...
S-adenosylmethionine metabolism and liver disease
Methionine is an essential amino acid that is metabolized mainly by the liver where it is converted to Sadenosylmethionine (SAMe) by the enzyme methionine adenosyltransferase. Although all mammalian cells synthesize SAMe...
Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report
For the last decade, the combination therapy of pegylated interferon (Peg-IFN) plus ribavirin (RBV) hasbeen considered as the standard of care treatment for chronic hepatitis C virus (HCV) infection. However, it has been...