Hepatoprotective activity of ethanol extract of PAVETTA INDICA LINN leaves
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 1
Abstract
Objective To investigate the hepatoprotective activity of ethanol extract of Pavetta Indica Linn leavesTraditionally the bark of Pavetta Indica Linn in decoction or pulverized is administered especially to children to correct visceral obstructions The decocted leaves are used externally to alleviate the pains caused by hemorrhoids The root pulverized and mixed with the ginger and ricewater is given in dropsy A local fomentation with the leaves is useful in relieving the pain of pilesParacetamol PCM Hepatotoxin generates free radicals and raised serum enzyme levelsSGPT SGOT AlkPho SAlb It causes necrosis congested vessels multifocal area of fatty changes nuclear disintegration sinusoidal dilation kuffer cell hyperplasia The reverse is considered as the index of hepatoprotective activity To screen hepatoprotective action this study has been taken upMaterials and Methods The acute liver damage in albino rats was induced byper oral administration of a single dose of 2000mgkg bw PCMsuspension in 05 Carboxy methyl cellulose CMC and chronic liver damage by giving the same dose of PCM on the 7th day The hepatoprotective activity was monitored biochemically by estimating S transaminase S bilirubin and S Proteinon the 8th day of experimentResults Ethanol extract of P Indica inhibited PCM induced liver toxicity in albino rats at 100mgkg and 200mgkg bw as assessed by the biochemical valuesConclusion Ethanol extract of ldquoP Indicardquo exhibited significant hepatoprotective activityKeywords Pavetta Indica Linn Hepatoprotective activity Silymarin Paracetamol Carboxy methyl cellulose
Authors and Affiliations
M. Premchand Singh, Varkung Valte, Indira Raleng, S. Losica RK
Keywords
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- EP ID EP478536
- DOI 10.18231/2393-9087.2018.0009
- Views 62
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