HEPATOPROTECTIVE ACTIVITY OF MAHONIA LESCHENAULTII TAKEDA. (ROOT WOOD AND ROOT BARK) ON COUNTRY MADE-LIQUOR (CML) INDUCED HEPATOTOXICITY IN RATS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2015, Vol 5, Issue 2
Abstract
The hepatoprotective potential of Mahonia leschenaultii Takeda. (root wood and root bark) extract was evaluated in Country-Made Liquor (CML)-induced hepatotoxicity in Wister rats. The rats were made hepatotoxic by administering (CML) (3 ml/100g body weight/day in two divided doses) and corn oil (1 ml/100g body weight /day in a single dose) orally for 21 days. The administration of root wood and root bark of Mahonia leschenaultii Takeda. extract (200 mg/kg body weight) mixed with tween 80 (0.5% w/w) orally from day 15to day 21 along with CML. The different biochemical parameters tested are ALAT, ASAT, ALP, LDH, TGL, total protein, total cholesterol, Albumin, total bilirubin and direct bilirubin. The results were compared with standard drugs i.e. Silymarin (70 mg/kg body weight) orally. The histopathological study was carried out and histopathological changes were observed and compared. The study showed that the extract of root wood and root bark of Mahonia leschenaultii Takeda. is definitely a hepatoprotective agent and help in reduction of liver damage.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP487612
- DOI 10.22270/jddt.v5i2.1062
- Views 51
- Downloads 0
SCOPE OF PHARMACIST ON FUTURE ASPECT
Pharmacy is a profession started in India early in 20th Century. Since then, it has undergone many changes educationally and professionally. The Profession of Pharmacy is Associate in Nursing integral a part of the aid s...
PRELIMINARY PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF AROGYAVARDHINI COMPOUND- AN EMERGING FORMULATED MEDICINE FOR METABOLIC SYNDROME
Context: Arogyavardhini Compound is an emerging formulated herbo-mineral formulation for treatment of metabolic syndrome. Metabolic syndrome is group of risk factors like, increased waist circumference, insulin resistanc...
PROTECTIVE EFFECT OF AQUEOUS EXTRACT POMEGRANATE PEEL AGAINST STERIGMATOCYSTIN TOXICITY IN RAT
ntroduction and Aim: Sterigmatocystin (Stg) a mycotoxin with mutagenic and carcinogenic properties is commonly found as the contaminant in grains and animal feeds. Pomegranate peel is a rich source of antioxidants, flavo...
AN APPROACH FOR DESIGNING OF TRANSDERMAL PATCHES FOR PROPHYLAXIS AND TREATMENT OF HIV/AIDS
Transdermal drug delivery is an alternative route for systemic drug delivery system, which minimizes the absorption of drugs and increases the bioavailability through systemic circulation. Currently available anti-HIV dr...
Oral dissolving film: present and future aspects
Over the past few decades, tendency toward innovative drug delivery systems has almightily increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a...