Hepatoprotective activity of methanolic extract of Barleria montana leaves in ethanol treated rats
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: The present study was undertaken to investigate the protective effect and possible mechanism of methanolic extract of Barleria montana (BM) on ethanol-induced rat hepatic injury. Method: This respective activity was assessed through monitoring liver function tests through the measurement of triglycerides, cholesterol, total protein, total bilirubin, serum enzymes like SGOT and SGPT and in vivo antioxidant parameters like lipid peroxidase, Superoxide dismutase(SOD) and catalase,. Further, hepatic tissues were also subjected to histopathological studies. Result: Pretreatment of BM methanolic extract (500mg/kg) reduced the fatty liver symptoms and significantly (p<0.001) inhibited the increase of respective serum enzyme levels. Conclusions: The results of the present study indicated that BM methanolic extract possess hepatoprotective effects which could act as an effective treatment for acute hepatic diseases.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP234113
- DOI 10.1016/S2222-1808(12)60257-6
- Views 93
- Downloads 0
B cell epitopes within VP40 of Ebola virus: the clue for vaccine development
no
Evaluating the antibacterial and anticandidal potency of mangrove, Avicennia marina
Objective: To evaluate the antibiotic activity of mangrove plant, Avicennia marina (A. marina) against human and shrimp pathogens and to delineate bioactive constituents by gas chromatography-mass spectrometer (GC-MS) pr...
Development and validation of a meat juice ELISA for the diagnosis of Fasciola hepatica in cattle in Cuba
Objective: To establish and validate a home-made ELISA for determination of antibodies against excretory-secretory proteins of Fasciola hepatica in bovine meat juice samples. Methods: The validity criteria of the assay w...
Semi-fild and fild studies on the effiacy of monomolecular surface fim (Agnique ®) against immature mosquitoes in the malarious areas of Iran
Objective: To investigate the efficacy of monomolecular surface film (Agnique® MMF) as a new method against immature stages of Anopheles mosquitoes in an malaria-endemic area. Methods: Semi-field and field trials were de...
Protective effect of pineapple (Ananas cosmosus) peel extract on alcohol-induced oxidative stress in brain tissues of male albino rats
Objective: To investigate the ability of pineapple peels to protect against alcohol-induced oxidative stress in brain tissues using male albino rat models. Methods: Response surface methodology (RSM) was used to design a...