HEPATOPROTECTIVE ACTIVITY OF THE EXTRACT OF CRATAEVA NURVALA BARK AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
The present work is focused on investigation of hepatoprotective activity of bark of Crataeva nurvala. It’s hepatoprotective activity was studied in the form of its aqueous and ethanolic extract and its isolated compound, against CCl4 induced hepatotoxicity in albino rats. The In-vitro study demonstrated the lowering of GPT and LDH level in isolated hepatocytes. Further more, an alteration in the level of biochemical markers, i.e., SGOT, SGPT, SALP and bilirubin were studied in-vivo on albino rats after CCl4 induced hepatic damage. Ethanolic extract (dose 250 mg/kg & 500 mg/kg) and isolated compound (dose 50 mg/kg) induced lowering of biochemical markers near to the normal levels in dose dependent manner, while there was no remarkable change with the aqueous extract (dose 250 mg/kg and 500mg/kg). Hence, the findings confirmed that ethanolic extract and isolated compound of C. nurvala bark possess hepatoprotective activity.
Authors and Affiliations
Reena Soni
Keywords
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