HEPATOPROTECTIVE EFFECT OF ECLIPTA ALBA AND PHYLLANTHUS FRATURNUS EXTRACT IN ANIMAL MODEL (RATS)
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 5
Abstract
This exercise was undertaken to study the hepatoprotective effect of Eclipta Alba and Phyllanthus fraturnus extract in CCl4 treated rats. CCl 4 induced fatty liver and liver cell necrosis in the rats. 60 male albino rats each weighing not less than 150 gm were divided into 6 groups with 10 animals in each group. The groups included-a control, group treated with CCl4, group-treated with Liv-52 and 3 groups receiving the plant extracts isolated and in combination. The rats were sacrificed under light ether anaesthesia and diagnostic estimations were done to assess the liver functions. Biochemical study indicated high levels of SGPT & SCOT in CCl4 treated rats: 450.33±161.25 and 605.66 ± 16.67 respectively. Eclipta alba managed to bring down the levels to 223.47 ± 105.79 and 444.67 ± 76.62 respectively whereas phyllanthus fraturnus treated rats indicated readings of 341.66 ± 22.47 and 428.33 ± 9.5 respectively . Histopathological studies revealed less congestion and very less fatty changes in the extract treated rats. Eclipta alba group had minimum abnormal changes. The profile appears to suggest marked beneficial effect of plant extracts in liver damage produced by CCl4.
Authors and Affiliations
Dr. Tushar Khachane, Dr. John Premendran
Keywords
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