Hepatoprotective effect of ethanolic extract of Curcuma caesia rhizomes in rats on paracetamol induced liver cirrhosis
Journal Title: Journal of Pharmacology and Biomedicine - Year 2017, Vol 1, Issue 2
Abstract
The objective of the study to evaluate the hepatoprotective effect of ethanolic extract of Curcuma caesia rhizomes in Wistar rats on paracetamol induced liver. Albino wistar rats were separated into five groups (n=6). Ethanolic extract of Curcuma caesia rhizomes was prepared and evaluated for its hepatoprotective efficacy against paracetamol (PCM) (2g/kg p.o.) induced hepatotoxicity in rats. Silymarin (100mg/kg p.o.) was used as standard. Levels of Serum glutamic pyruvate transaminase (SGPT), Serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), and total protein was evaluated along with histopathological investigation in various experimental groups of rats. Present study suggested thatthe protective effect of ethanolic extract of Curcuma caesia against paracetamol induced hepatic damage.
Authors and Affiliations
Rizwan Arfi, Sanjay Dwivedi
Keywords
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Hepatoprotective effect of ethanolic extract of Curcuma caesia rhizomes in rats on paracetamol induced liver cirrhosis
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