HEPATOPROTECTIVE EFFECT OF MALACHRA CAPITATA (L.) AGAINST CARBON TETRA CHLORIDE-INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS
Journal Title: Int J of Pharm Rev& Res - Year 2012, Vol 2, Issue 2
Abstract
The present study to investigate the phytoconstituents, acute oral toxicity and hepatoprotective activity of aqueous extract of Malachra capitata (L.) (AMC) using CCl4 induced hepatotoxicity in male Wistar albino rats. The AMC at doses of 100, 200 and 400mg/kg, p.o and the standard drug Liv.52 (40mg/kg, p.o) were administered for 7 days in CCl4 intoxicated rats. The hepatoprotective activity was assessed by using various biochemical parameters like SGOT, SGPT, alkaline phosphatase (ALP) and acid phosphatase (ACP), also total bilirubin and urea. The biochemical changes and histopathological studies were observed on 4th and 8th day. AMC at tested doses significantly decrease (P<0.001) the elevated levels of the hepatic enzymes, total bilirubin and urea in a dose dependent manner after 3days whereas it’s subsequent return towards near normal after 7days indicating the recovery of hepatic cells. The AMC afforded significant protection against CCl4 induced hepatocellular injury
Authors and Affiliations
N. Sriram , K. Vinoth Kumar2 , Shubhrajit Mantry3 , S. Sakthivel4 , Pandith Shiva Prasad5
Keywords
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