Hepatoprotective effect of olive oil and camel milk on acetaminophen-induced liver toxicity in mice
Journal Title: International Journal of Medical Science and Public Health - Year 2017, Vol 6, Issue 1
Abstract
Background: Acetaminophen overdose is a major cause of drug-induced liver failure. Objective: To investigate the hepatoprotective effects of Extra Virgin Olive Oil (EVOO) and camel Milk (CM) on histopathological changes and changes in oxidant &antioxidant systems in liver caused by acetaminophen(APAP)-induced liver toxicity in mice. Materials and Methods: Mice were randomly divided into 6 groups, with 6 mice per group; control, EVOO,CM, APAP, EVOO + APAP, CM +APAP. In APAP group, mice were treated with single dose acetaminophen (500mg/kg).Prophylactic groups were given EVOO and CM for 28 days before APAP administration, in the same dose as that of the toxic group. Liver enzymes, lipid profile, malondialdehyde (MDA) and total antioxidant (TAC) activities were assessed. Result: In the toxicity group, increased concentrations of MDA and decreased TAC activities were found compared to the control groups (p < 0.05), with elevated liver enzymes. EVOO and CM treatment resulted in hepatoprotective effects as evident by a significant decrease in serum liver enzymes and liver malondialdehyde, with a synchronous increase in TAC compared to acetaminophen-treated group (p<0.05). Histopathological examination showed extensive centrilobular necrosis, hydropic degeneration of hepatocytes in APAP group. These changes were alleviated in the pretreatment groups with EVOO and CM. Conclusion: The present study showed that olive oil and camel milk have hepatoprotective action against acetaminophen induced hepatotoxicity. Pretreatment with EVOO and CM markedly alleviates acetaminophen hepatotoxicity in mice possibly, in part, through anti-oxidative effects
Authors and Affiliations
Mahrous Abdel Basset Ibrahim, Farooq Ahmed Wani, Shaik Rahiman
Keywords
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- EP ID EP299149
- DOI 10.5455/ijmsph.2017.07092016614
- Views 59
- Downloads 0
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