Hepatoprotective Effect of Roselle (Hibiscussabdariffa L.) inN-Diethylnitrosamine Induced Liver Damage inRats
Journal Title: International Journal Of Medical Science And Clinical Research Studies - Year 2023, Vol 3, Issue 3
Abstract
Introduction:Liver damage due N-diethylnitrosamine (DEN) is a global health challenge. The aim of this study was to assess the efficacy of roselle (Hibiscus sabdariffaL.) calyces’ water-extract as a Hepatoprotective material against liver damage induced by DEN in rats.Material and methods:Twenty-five (25) adult female albino Wistar rats were grouped randomly into five groups (Gs): G1, Normal healthy animals (act as control); G2, DEN; G3, Roselle extract; G4, DEN + roselle-extract; G5, DEN + nanoselenium. Tissue malondialdehyde (MDA) as oxidative stress marker, and antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT) were measured. Also, caspase-3 as apoptotic marker and tumor necrosis factor-alpha (TNF-) as inflammatory factor, were assessed. Results:The results revealed decrease in MAD level and significant increase in antioxidant markers, SOD and CAT in DEN-group compared with control group. Moreover high increase in apoptotic marker, caspase-3; and significant decrease in TNF-in DEN-group were recorded compared with normal control. Administration of roselle-extract led to significant increase in MDA and decrease in SOD and CAT parameters. In addition, high decrease in caspase-3 and increase in TNF-was noticed. These findings were ensured by histopathological results.Conclusion:The roselle-extract improve liver architecture, and might be involved in the hepatoprotective activity against DEN exposure. Further studies are needed for elucidation clinical applications of the plant bioactive materials and explore its mode of action in attenuating and preventing carcinogenesis.
Authors and Affiliations
Adam O. Abaker , Abdelkareem A. Ahmed, Eman I. Kandil , Eman N. Aly ,Saber Y. Adam
Keywords
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- EP ID EP739848
- DOI 10.47191/ijmscrs/v3-i3-10
- Views 32
- Downloads 0
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