Hepatoprotective Effect of Solanum xanthocarpum in Paracetamol Induced Hepatic Damage in Experimental Animals
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2014, Vol 2, Issue 2
Abstract
Aim: The present study aims to evaluate the hepatoprotactive effect of ethanol extract of Solanum xanthocarpum (EESX) leaf on paracetamol induced hepatic damaged in experimental rats. Materials and methods: Paracetamol (3g/kg, P.o) was administered a single dose to induce hepatotoxicity. EESX (200mg and 400mg/kg, P.o) and silymarin (25mg/kg, P.o) were administered once daily for 8 days. The degree of hepatoprotection was measured using serum transaminases (AST and ALT), alkaline phosphatase, total protein and total bilirubin levels. Histopathological changes of liver sample were also observed. Results: EESX treatment showed significant dose dependent restoration of serum enzymes, total protein and bilirubin levels. Improvements in hepatoprotection and morphological and histopathological changes were also observed in ethanol extract of Solanum xanthocarpum treated rats. Conclusion: The result of this study strongly indicated that ethanol extract of Solanum xanthocarpum has got a hepatoprotective action against paracetamol induced hepatic damage in rats
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