Hepatotoxic effect of ethanolic extract of syzygium cumini. Linn leaves on experimental animals
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 3
Abstract
ABSTRACT Syzygium cumini. Linn Leaves were widely used as good medication for several diseases like antimicrobial, cancer, antihypertensive etc. Aim: The main goal of our study was to explore the acute and sub-chronic oral toxic effects of Ethanolic Extract of Syzygium cumini. Linn Leaves on experimental animals. Materials and methods: Acute toxicity study was carried out by following OECD guideline no. 423. The different doses like 500, 1000, 2000, 3000, 4000 and 5000mg/Kg body weight were administered orally to the different groups of animals and observed for 24 hr after dosing and also observed for 14 days without giving drug. In sub- chronic oral toxicity study, the parameters were after administering daily oral doses of 1250, 2500 and 5000 mg/kg body weight for 28 days to the rats. Results: Body weights of the rats observed weekly and Biochemical, hematological, histopathological assessments and relative organ weights of the rats were observed on 29th day. Conclusion: By observing the hematological, biochemical parameters and the histopathological studies it is finally concluded that Ethanolic extract of Syzygium cumini leaves produces severe inflammation and fibrosis on Liver at oral doses of 1250, 2500 and 5000mg/kg body weight.
Authors and Affiliations
M. Sekar M. Sekar
Keywords
Related Articles
- EP ID EP410902
- DOI -
- Views 131
- Downloads 0
A new looming of Middle East respiratory syndrome coronavirus MERSCoV
Middle East Respiratory Syndrome Coronavirus is the species of genus Beta Coronavirus. A novel human coronaviruses are single-stranded RNA. They are distinct from SARS and common cold viruses. First case of MERS-CoV was...
Bambusa arundinacea (vanshlochan): An overview
Bamboo species are thought to be originally from Central China, but are now found in many temperate and semi- tropical regions around the world. There are approximately 75 species and 200 varieties of Phyllostachys. Bamb...
A Review on Alternative Therapy for Acne
Acne is the cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production, and it is characterized by both inflammatory (papules, pustules and nodules) and noninflammatory (comedo...
Pharmacovigilance: The conscientious today for safe tomorrow
Pharmacovigilance is the Science and activity relating to detection, assessment, understanding and prevention of adverse effects or any other possible medicine-related problems. There are guidelines and regulations from...
Hepatoprotective effects of l-carnitine against cyclosporine A-induced liver injury in white albino rats; a newly proposed mechanism of action
It is well documented that l-carnitine (L-C) has protective effects against various types of injury. Although its antioxidant action has been reported as a major mechanism, other suggested pathways may be implicated in i...