Hepatotoxic effect of ethanolic extract of syzygium cumini. Linn leaves on experimental animals
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 3
Abstract
ABSTRACT Syzygium cumini. Linn Leaves were widely used as good medication for several diseases like antimicrobial, cancer, antihypertensive etc. Aim: The main goal of our study was to explore the acute and sub-chronic oral toxic effects of Ethanolic Extract of Syzygium cumini. Linn Leaves on experimental animals. Materials and methods: Acute toxicity study was carried out by following OECD guideline no. 423. The different doses like 500, 1000, 2000, 3000, 4000 and 5000mg/Kg body weight were administered orally to the different groups of animals and observed for 24 hr after dosing and also observed for 14 days without giving drug. In sub- chronic oral toxicity study, the parameters were after administering daily oral doses of 1250, 2500 and 5000 mg/kg body weight for 28 days to the rats. Results: Body weights of the rats observed weekly and Biochemical, hematological, histopathological assessments and relative organ weights of the rats were observed on 29th day. Conclusion: By observing the hematological, biochemical parameters and the histopathological studies it is finally concluded that Ethanolic extract of Syzygium cumini leaves produces severe inflammation and fibrosis on Liver at oral doses of 1250, 2500 and 5000mg/kg body weight.
Authors and Affiliations
M. Sekar M. Sekar
Keywords
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