Hepatotoxicity in Rabbits resulting from sub-chronic Exposure to Bioaccumulated Herbicide, Butachlor® in Beans (phaseolus vulgaris) Leaf forages
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Bioaccumulation of herbicides is a potential hazard for man and animals. In a previous study conducted by our team of researchers, leaves from experimental beans that were treated with butachlor® at pre-emergent were found to have bioaccumulated residues of the herbicide at 6 weeks. The control beans without exposure to herbicide had no trace of butachlor® detected in the leaves but the test beans which were treated with 260mg/m2 (recommended concentration) had 0.10 ppm while 290 and 320 mg/m2 induced a correspondingly increased bioaccumulation value of 0.13 and 0.20ppm. Sub-chronic (28-day) exposure through feeding of experimental rabbits with bean forages containing the different concentrations of the bioaccumulatedbutachlor® was then conducted. Thereafter, assay of rabbit serum biomarkers of hepatotoxicity [alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP)] was carried out. Histopathological studies of liver samples from the separate test animal groups were also performed. There was a highly significant (p<0.01) concentration and time dependent increases in serum liver enzymes particularly AST and ALT of rabbits exposed to bioaccumulatedbutachlor® in bean leaf forages relative to the control. Evidence from histopathological studies on day 28 also corroborated with the results of the rabbit liver enzyme assays. Lesions of hepatocellular damage degenerated from cellular changes to necrosis of hepatocytes and initiation of fibrosis with consumption of 0.10, 0.13 and 0.20 ppm amounts of the herbicide residue in bean leaf forages respectively. Herbicide, butachlor® could bioaccumulate in beans leaves with a potential to cause hepatotoxicity in forage eating rabbits and probably other animals.
Authors and Affiliations
Enefe, Ndidi G, Adeyemo, Bola T, Madubuike, Stella A, Ode, Julius O
Keywords
Related Articles
- EP ID EP395430
- DOI 10.9790/3008-1303051219
- Views 63
- Downloads 0
Detection and Endodontic Management of Radix Paramolaris - A Rare Case Report
Normally Mandibular Molars Have Two Roots, Mesial And Distal. But Sometimes They Present A Variation Called Radix Entomolaris, Where The Tooth Has An Extra Root Attached To Its Lingual Aspect And Very Rarely Radix Paramo...
Primary Tuberculous Otitis Media: A Case Report
Tuberculosis is a chronic granulomatous disease that can affect any part of temporal bone. Primary tuberculous otitis media is a rare disease that is clinically variable and non-specific. Tuberculous otitis media may be...
Antenatal Diagnosis of Upper Airway Obstruction with Bilateral Renal Agenesis: A Rare Case
Congenital high airway obstruction syndrome (CHAOS) is the obstruction of the fetal upper airways, which may be partial or complete. It is usually incompatible with life. Prenatal recognition of the disease is quite impo...
The knowledge, attitude and awareness of infant oral health care among gynecologists and pediatricians
Dental caries comprise the single most chronic disease affecting children today. Evidence increasingly suggests that for successful prevention of dental caries, preventive interactions must begin early. Gynecologists and...
Quality Of Life of Patients with Type 2 Diabetes
Introduction: Quality of life is important for people with diabetes and their healthcare providers for several reasons. This is because many people who suffer from diabetes and who have poor quality of life, often have l...